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Rabbit Polyclonal Phospho-WRN (S1141) antibody (STJ90561)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for WRN (phospho Ser1141) Polyclonal Antibody.
Check alternative names for the antibodyExpand
WRN antibody, RECQ3 antibody, RECQL2 antibody,|DKFZp686C2056 antibody|DNA helicase antibody|DNA helicase, RecQ like type 3 antibody|Exonuclease WRN antibody|HGNC 12791 antibody|OTTHUMP00000225301 antibody|RecQ protein-like 2 antibody|RecQ-like type 3 antibody|RecQ3 antibody|RECQL2 antibody|RECQL3 antibody|Werner syndrome ATP-dependent helicase antibody|Werner syndrome helicase antibody|Werner syndrome protein antibody|Werner syndrome, RecQ helicase like antibody|WRN antibody|WRN_HUMAN antibody|Anti-Werner's syndrome helicase WRN antibody [8H3] (ab66601)
SCBT cat No: To be updated
WRN (phospho Ser1141) Polyclonal Antibody
|Catalogue No.|| |
Phospho-WRN (S1141) Polyclonal Antibody detects endogenous levels of WRN protein only when phosphorylated at S1141.
Synthesized phospho-peptide derived from WRN (phospho Ser1141) at AA range 1080-1160
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
WRN (phospho Ser1141) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
WRN (phospho Ser1141) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Werner syndrome ATP-dependent helicase antibody, DNA helicase, RecQ-like type 3 antibody, RecQ3 antibody, Exonuclease WRN antibody, RecQ protein-like 2 antibody
|Protein names|| |
Werner syndrome ATP-dependent helicase , DNA helicase, RecQ-like type 3 , RecQ3 , Exonuclease WRN , RecQ protein-like 2
|Protein function|| |
Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3′->5′ exonuclease activity towards double-stranded DNA with a 5′-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation. / ATP + H2O = ADP + phosphate. / Mg2+
|Involvement in disease|| |
Werner syndrome (WRN) [MIM:277700]: A rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. . Note: The disease may be caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the helicase family. RecQ subfamily. / Contains 1 3′-5′ exonuclease domain. / Contains 1 helicase ATP-binding domain. / Contains 1 helicase C-terminal domain. / Contains 1 HRDC domain.
|Protein post-translational modifications|| |
Phosphorylated by PRKDC.
|Protein cellular localization|| |
Nucleus > nucleolus / Nucleus / Nucleus > nucleoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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