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Rabbit Polyclonal Phospho-WWOX (Y33) antibody (STJ90971)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for WWOX (phospho Tyr33) Polyclonal Antibody.
Check alternative names for the antibodyExpand
WWOX antibody, FOR antibody, SDR41C1 antibody, WOX1 antibody,||
SCBT cat No: To be updated
WWOX (phospho Tyr33) Polyclonal Antibody
|Catalogue No.|| |
Phospho-WWOX (Y33) Polyclonal Antibody detects endogenous levels of WWOX protein only when phosphorylated at Y33.
Synthesized phospho-peptide derived from WWOX (phospho Tyr33) at AA range 10-90
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
WWOX (phospho Tyr33) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
WWOX (phospho Tyr33) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
WW domain-containing oxidoreductase antibody, Fragile site FRA16D oxidoreductase antibody, Short chain dehydrogenase/reductase family 41C member 1 antibody
|Protein names|| |
WW domain-containing oxidoreductase , Fragile site FRA16D oxidoreductase , Short chain dehydrogenase/reductase family 41C member 1
|Protein function|| |
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
|Protein tissue specificity|| |
Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
|Protein sequence and domain|| |
The WW 1 domain mediates interaction with TP53, and probably TP73, TFAP2C, LITAF and WBP1. / Belongs to the short-chain dehydrogenases/reductases (SDR) family. / Contains 2 WW domains.
|Protein post-translational modifications|| |
Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation. / Ubiquitinated when phosphorylated by TNK2, leading to its degradation.
|Protein cellular localization|| |
Cytoplasm / Nucleus / Mitochondrion / Golgi apparatus
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St John’s Laboratory Ltd.
|Product type|| |
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