Rabbit Polyclonal Phospho-WWOX (Y33) antibody (STJ90971)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-WWOX (Y33) antibody (STJ90971)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for WWOX (phospho Tyr33) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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WWOX antibody, FOR antibody, SDR41C1 antibody, WOX1 antibody,||
SCBT cat No: To be updated

 

Name

WWOX (phospho Tyr33) Polyclonal Antibody

Catalogue No.

STJ90971

Reactivity

Human, Mouse

Specificity

Phospho-WWOX (Y33) Polyclonal Antibody detects endogenous levels of WWOX protein only when phosphorylated at Y33.

Immunogen

Synthesized phospho-peptide derived from WWOX (phospho Tyr33) at AA range 10-90

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

55 kDa

Formulation

WWOX (phospho Tyr33) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

WWOX (phospho Tyr33) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

WW domain-containing oxidoreductase antibody, Fragile site FRA16D oxidoreductase antibody, Short chain dehydrogenase/reductase family 41C member 1 antibody

Database links

Human UniProt/Swiss-Prot:Q96KM3;Human Entrez Gene: 51741;

Protein names

WW domain-containing oxidoreductase , Fragile site FRA16D oxidoreductase , Short chain dehydrogenase/reductase family 41C member 1

Protein function

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.

Protein tissue specificity

Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.

Protein sequence and domain

The WW 1 domain mediates interaction with TP53, and probably TP73, TFAP2C, LITAF and WBP1. / Belongs to the short-chain dehydrogenases/reductases (SDR) family. / Contains 2 WW domains.

Protein post-translational modifications

Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation. / Ubiquitinated when phosphorylated by TNK2, leading to its degradation.

Protein cellular localization

Cytoplasm / Nucleus / Mitochondrion / Golgi apparatus

Research area

All research areas>Tumor Suppressor/Apoptosis>WWOX
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize WWOX (phospho Tyr33) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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