Rabbit polyclonal PIBF1 antibody (A3072)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PIBF1 antibody (A3072)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:1000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PIBF1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

PIBF antibody, CEP90 antibody, C13orf24 antibody, RP11-505F3.1 antibody
C13orf24 antibody|KIAA1008 antibody|PIBF 1 antibody|PIBF antibody|PIBF1 antibody|PIBF1_HUMAN antibody|Progesterone immunomodulatory binding factor 1 antibody|Progesterone induced blocking factor 1 antibody|Progesterone-induced-blocking factor 1 antibody|RP11 505F3.1 antibody|Anti-C13orf24 antibody (ab151491)

SCBT cat No: sc-376840|sc-166372|sc-166904|sc-271504|sc-99129|sc-48266|

Name

Rabbit polyclonal PIBF1 antibody

Catalogue No.

A3072

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human PIBF1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:1000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 90kDa/Observed: Refer to Figures

Formulation

PIBF1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PIBF1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PIBF antibody, CEP90 antibody, C13orf24 antibody, RP11-505F3.1 antibody

Database links

Human UniProt/Swiss-Prot:Q8WXW3

Protein names

PIBF, CEP90, C13orf24, RP11-505F3.1

Protein function

Isoform 1: Pericentriolar protein required to maintain mitotic spindle pole integrity . Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation . Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 .; Isoform 4: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect . Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein .

Protein tissue specificity

Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon . Expressed in the first trimester pregnancy decidua . Localized to extravillous cytotrophoblast (at protein level). Also found in syncytiotrophoblast and part of the villous cytotrophoblast. Isoform 1 is expressed in first trimester and term villous trophoblast; trophoblast cells can additionally express other isoforms . Overexpresed in solid tumors from stomach and uterus and in cells from ovary, cervical, breast, lymphoma and leukemia cancer .

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm . Secreted . Note: In progesterone-treated astrocytoma cells a 57 kDa protein and isoform 1 (90 kDa) have been described, both being located in the intracellular medium and secreted. Respective predominant forms are isoform 1 in the intracellular and the 57 kDa protein in the extracellular medium .; Isoform 1: Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Secreted . Note: Localizes to centriolar satellites throughout the cell cycle.; Isoform 4: Secreted . Note: Secreted by progesterone-treated lymphocytes .

Background

Progesterone-induced-blocking factor 1 is a protein that in humans is encoded by the PIBF1 gene. It has been shown to localize to the centrosome and has also been named CEP90. Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.

Note

AntibodyPlus can customize PIBF1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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