Rabbit polyclonal PICK1 antibody (A1519)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PICK1 antibody (A1519)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

MGC15204 antibody, PICK antibody, PRKCABP antibody
dJ1039K5 antibody|MGC15204 antibody|OTTHUMP00000028509 antibody|PICK 1 antibody|Pick1 antibody|PICK1_HUMAN antibody|PRKCA binding protein antibody|PRKCA-binding protein antibody|PRKCABP antibody|Protein interacting with C kinase 1 antibody|Protein interacting with PRKCA antibody|Protein interacting with PRKCA 1 antibody|Protein kinase C alpha binding protein antibody|Protein kinase C-alpha-binding protein antibody|Protein that interacts with C kinase 1 antibody|Anti-PICK1 antibody (ab3420)

SCBT cat No: sc-166591|sc-365403|sc-74592|sc-390479|sc-166654|sc-11410|sc-9539|

Name

Rabbit polyclonal PICK1 antibody

Catalogue No.

A1519

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human PICK1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 47kDa/Observed: Refer to Figures

Formulation

PICK1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PICK1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MGC15204 antibody, PICK antibody, PRKCABP antibody

Database links

Human UniProt/Swiss-Prot:Q9NRD5

Protein names

MGC15204, PICK, PRKCABP

Protein function

Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The AH domain mediates binding to F-actin.; The unoccupied PDZ domain is probably involved in allosteric modulation by forming an intramolecular bridge with the AH domain leading to a ‘closed’ formation. Binding of a PDZ ligand, such as GRIA2, allows enhanced interactions with F-actin and the Arp2/3 complex thus enhanced inhibition of actin polymerization (By similarity).Contains 1 AH domain.; Contains 1 PDZ (DHR) domain.

Protein post-translational modifications

Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.; Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD).

Protein cellular localization

Cytoplasm, perinuclear region. Membrane ; Peripheral membrane protein . Membrane ; Lipid-anchor . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell junction, synapse, synaptosome . Cytoplasm, cytoskeleton . Note: Also membrane-associated, present at excitatory synapses.

Background

Protein interacting with C kinase 1 (PICK1) is a PDZ-domain containing protein that is located in the perinuclear region and is phosphorylated in response to PKC alpha activation. PKC alpha, which is essential for the regulation of proliferation and differentiation in numerous cell types, contains within its catalytic region a PDZ-binding domain that is absent from other PKC isoforms. Mutation of the PICK1 PDZ domain inhibits the binding of PICK1 to PKC alpha. PICK1 also interacts with the carboxy terminus of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor, a neurotransmitter receptor located at excitatory synapses, suggesting that PICK1 plays a role in the modulation of synaptic transmission by targeting and anchoring AMPA to specific synapses.

Note

AntibodyPlus can customize PICK1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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