Rabbit polyclonal PIN1 antibody (A2106)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PIN1 antibody (A2106)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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DOD antibody, UBL5 antibody
DOD antibody|DODO, Drosophila, homolog of antibody|FLJ40239 antibody|FLJ77628 antibody|MGC10717 antibody|NIMA interacting 1 antibody|Peptidyl prolyl cis trans isomerase NIMA interacting 1 antibody|Peptidyl prolyl cis/trans isomerase NIMA interacting antibody|Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody|Peptidyl-prolyl cis-trans isomerase pin1 antibody|Peptidylprolyl cis/trans isomerase NIMA interacting 1 antibody|Pin 1 antibody|Pin1 antibody|PIN1_HUMAN antibody|PPIase Pin1 antibody|Prolyl isomerase antibody|Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1 antibody|Protein NIMA interacting 1 antibody|Rotamase Pin1 antibody|UBL 5 antibody|UBL5 antibody|Anti-Pin1 antibody [EP1479Y] (ab76309)

SCBT cat No: sc-81533|sc-7412|sc-7409|sc-365028|sc-271441|sc-46660|sc-15340|sc-7413|

Name

Rabbit polyclonal PIN1 antibody

Catalogue No.

A2106

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PIN1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 18kDa/Observed: Refer to Figures

Formulation

PIN1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PIN1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DOD antibody, UBL5 antibody

Database links

Human UniProt/Swiss-Prot:Q13526

Protein names

DOD, UBL5

Protein function

Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins . Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK . Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation . Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner . Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN .

Protein tissue specificity

The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells.

Protein sequence and domain

The WW domain is required for the interaction with STIL and KIF20B.Contains 1 PpiC domain.; Contains 1 WW domain.

Protein post-translational modifications

Phosphorylation at Ser-71 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its ability to induce centrosome amplification, chromosome instability and cell transformation.

Protein cellular localization

Nucleus . Nucleus speckle . Cytoplasm . Note: Colocalizes with NEK6 in the nucleus . Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization .

Background

Pin1, a member of the parvulin family of peptidyl-prolyl isomerases (PPIase), has been implicated in the G2/M transition of the mammalian cell cycle (1-6). Pin1 is a small (18 kDa) protein with two distinct functional domains: an amino-terminal WW domain and a carboxy-terminal PPlase domain. Pin1 interacts with several mitotic phosphoproteins, including Plk1, cdc25C and cdc27, and is thought to act as a phosphorylation-dependent PPlase for these target molecules (7-9).

Research area

All research areas>Signaling Intermediates>Protein NIMA-Interacting
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize PIN1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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