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Rabbit polyclonal PINK1 antibody (A7131)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal PINK1 antibody.
Check alternative names for the antibodyExpand
BRPK antibody, PARK6 antibody
BRPK antibody|FLJ27236 antibody|mitochondrial antibody|PARK 6 antibody|PARK6 antibody|Phosphatase and Tensin Homolog antibody|PINK 1 antibody|PINK1 antibody|PINK1_HUMAN antibody|Protein kinase BRPK antibody|PTEN induced putative kinase 1 antibody|PTEN induced putative kinase protein 1 antibody|PTEN-induced putative kinase protein 1 antibody|Serine/threonine kinase PINK1 mitochondrial antibody|Serine/threonine protein kinase PINK1 mitochondrial antibody|Serine/threonine-protein kinase PINK1 antibody|Anti-PINK1 antibody (ab23707)
SCBT cat No: sc-32584|sc-33796|sc-32583|
Rabbit polyclonal PINK1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human PINK1
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 63kDa/Observed: Refer to figures
PINK1 antibody was tube-contained.
PINK1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
BRPK antibody, PARK6 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at ‘Ser-65’ of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form .
|Protein tissue specificity|| |
Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Autophosphorylation at Ser-228 and Ser-402 is essential for Parkin/PARK2 recruitment to depolarized mitochondria.; Two shorter forms of 55 kDa and 48 kDa seem to be produced by proteolytic cleavage and localize mainly in cytosol.
|Protein cellular localization|| |
Mitochondrion outer membrane; Single-pass membrane protein . Cytoplasm, cytosol . Note: Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol.
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.
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|Product type|| |
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