Rabbit polyclonal PINK1 antibody (A7131)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PINK1 antibody (A7131)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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BRPK antibody, PARK6 antibody
BRPK antibody|FLJ27236 antibody|mitochondrial antibody|PARK 6 antibody|PARK6 antibody|Phosphatase and Tensin Homolog antibody|PINK 1 antibody|PINK1 antibody|PINK1_HUMAN antibody|Protein kinase BRPK antibody|PTEN induced putative kinase 1 antibody|PTEN induced putative kinase protein 1 antibody|PTEN-induced putative kinase protein 1 antibody|Serine/threonine kinase PINK1 mitochondrial antibody|Serine/threonine protein kinase PINK1 mitochondrial antibody|Serine/threonine-protein kinase PINK1 antibody|Anti-PINK1 antibody (ab23707)

SCBT cat No: sc-32584|sc-33796|sc-32583|

Name

Rabbit polyclonal PINK1 antibody

Catalogue No.

A7131

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PINK1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 63kDa/Observed: Refer to figures

Formulation

PINK1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PINK1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BRPK antibody, PARK6 antibody

Database links

Human UniProt/Swiss-Prot:Q9BXM7

Protein names

BRPK, PARK6

Protein function

Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at ‘Ser-65’ of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form .

Protein tissue specificity

Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.

Protein sequence and domain

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.; Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylation at Ser-228 and Ser-402 is essential for Parkin/PARK2 recruitment to depolarized mitochondria.; Two shorter forms of 55 kDa and 48 kDa seem to be produced by proteolytic cleavage and localize mainly in cytosol.

Protein cellular localization

Mitochondrion outer membrane; Single-pass membrane protein . Cytoplasm, cytosol . Note: Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol.

Background

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Note

AntibodyPlus can customize PINK1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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