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Rabbit polyclonal PIP5K1A antibody (A7941)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal PIP5K1A antibody.
Check alternative names for the antibodyExpand
68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha antibody|Phosphatidylinositol 4 phosphate 5 kinase type I alpha antibody|Phosphatidylinositol-4-phosphate 5-kinase type I alpha antibody|Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha antibody|PI4P5K Ia antibody|PI51A_HUMAN antibody|PIP5K A antibody|PIP5K1-alpha antibody|Pip5k1a antibody|PIP5KIalpha antibody|PtdIns(4)P-5-kinase 1 alpha antibody|Anti-PIP5K1 alpha antibody (ab137441)
SCBT cat No: sc-11772|sc-376634|sc-11774|sc-377021|sc-515416|sc-376195|sc-398687|
Rabbit polyclonal PIP5K1A antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human PIP5K1A
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 63kDa/Observed: Refer to figures
PIP5K1A antibody was tube-contained.
PIP5K1A antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.
|Protein tissue specificity|| |
Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver.
|Protein sequence and domain|| |
Contains 1 PIPK domain.
|Protein cellular localization|| |
Cell membrane. Cytoplasm . Nucleus speckle. Cell projection, ruffle. Note: Colocalizes with RAC1 at actin-rich membrane ruffles. Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs.
AntibodyPlus can customize PIP5K1A antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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