Rabbit polyclonal PLA2R1 antibody (A10068)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PLA2R1 antibody (A10068)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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180 kDa secretory phospholipase A2 receptor antibody|C-type lectin domain family 13 member C antibody|CLEC13C antibody|M type receptor antibody|M-type receptor antibody|Phospholipase A2 receptor 1 antibody|PLA2 R antibody|PLA2-R antibody|PLA2G1R antibody|PLA2IR antibody|PLA2R antibody|PLA2R_HUMAN antibody|PLA2R1 antibody|Soluble PLA2-R antibody|Soluble PLA2R antibody|Soluble secretory phospholipase A2 receptor antibody|Anti-PLA2R antibody [12-6-5] (ab211490)

SCBT cat No:

Name

Rabbit polyclonal PLA2R1 antibody

Catalogue No.

A10068

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human PLA2R1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 169kDa/Observed: Refer to figures

Formulation

PLA2R1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PLA2R1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:Q13018

Protein function

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

Protein tissue specificity

Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level.

Protein sequence and domain

C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.; The endocytosis signal probably mediates endocytosis via clathrin-coated pits.Contains 8 C-type lectin domains.; Contains 1 fibronectin type-II domain.; Contains 1 ricin B-type lectin domain.

Protein post-translational modifications

The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity).

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein .; Soluble secretory phospholipase A2 receptor: Secreted .; Isoform 2: Secreted .

Note

AntibodyPlus can customize PLA2R1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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