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Rabbit polyclonal PLAT antibody (A5655)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal PLAT antibody.
Check alternative names for the antibodyExpand
TPA antibody, T-PA antibody
Alteplase antibody|DKFZp686I03148 antibody|Plasminogen activator tissue antibody|Plasminogen activator tissue type antibody|PLAT antibody|Reteplase antibody|t PA antibody|T Plasminogen Activator antibody|t-PA antibody|T-plasminogen activator antibody|Tissue plasminogen activator (t PA) antibody|Tissue type plasminogen activator antibody|Tissue-type plasminogen activator chain B antibody|tPA antibody|TPA_HUMAN antibody|TPA1 antibody|Anti-TPA Tissue Plasminogen Activator antibody [EPR7232(2)] (ab157469)
SCBT cat No:
Rabbit polyclonal PLAT antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human PLAT
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 62kDa/Observed: Refer to Figures
PLAT antibody was tube-contained.
PLAT antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
TPA antibody, T-PA antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
|Protein tissue specificity|| |
Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
|Protein sequence and domain|| |
Both FN1 and one of the kringle domains are required for binding to fibrin.; Both FN1 and EGF-like domains are important for binding to LRP1.; The FN1 domain mediates binding to annexin A2.; The second kringle domain is implicated in binding to cytokeratin-8 and to the endothelial cell surface binding site.Belongs to the peptidase S1 family.; Contains 1 EGF-like domain.; Contains 1 fibronectin type-I domain.; Contains 2 kringle domains.; Contains 1 peptidase S1 domain.
|Protein post-translational modifications|| |
The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.; Differential cell-specific N-linked glycosylation gives rise to two glycoforms, type I (glycosylated at Asn-219) and type II (not glycosylated at Asn-219). The single chain type I glycoform is less readily converted into the two-chain form by plasmin, and the two-chain type I glycoform has a lower activity than the two-chain type II glycoform in the presence of fibrin.; N-glycosylation of Asn-152; the bound oligomannosidic glycan is involved in the interaction with the mannose receptor.; Characterization of O-linked glycan was studied in Bowes melanoma cell line.
|Protein cellular localization|| |
Secreted, extracellular space.
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
AntibodyPlus can customize PLAT antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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