Rabbit polyclonal PLAT antibody (A5655)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PLAT antibody (A5655)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

TPA antibody, T-PA antibody
Alteplase antibody|DKFZp686I03148 antibody|Plasminogen activator tissue antibody|Plasminogen activator tissue type antibody|PLAT antibody|Reteplase antibody|t PA antibody|T Plasminogen Activator antibody|t-PA antibody|T-plasminogen activator antibody|Tissue plasminogen activator (t PA) antibody|Tissue type plasminogen activator antibody|Tissue-type plasminogen activator chain B antibody|tPA antibody|TPA_HUMAN antibody|TPA1 antibody|Anti-TPA Tissue Plasminogen Activator antibody [EPR7232(2)] (ab157469)

SCBT cat No:

Name

Rabbit polyclonal PLAT antibody

Catalogue No.

A5655

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PLAT

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 62kDa/Observed: Refer to Figures

Formulation

PLAT antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PLAT antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

TPA antibody, T-PA antibody

Database links

Human UniProt/Swiss-Prot:P00750

Protein names

TPA, T-PA

Protein function

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.

Protein tissue specificity

Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.

Protein sequence and domain

Both FN1 and one of the kringle domains are required for binding to fibrin.; Both FN1 and EGF-like domains are important for binding to LRP1.; The FN1 domain mediates binding to annexin A2.; The second kringle domain is implicated in binding to cytokeratin-8 and to the endothelial cell surface binding site.Belongs to the peptidase S1 family.; Contains 1 EGF-like domain.; Contains 1 fibronectin type-I domain.; Contains 2 kringle domains.; Contains 1 peptidase S1 domain.

Protein post-translational modifications

The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.; Differential cell-specific N-linked glycosylation gives rise to two glycoforms, type I (glycosylated at Asn-219) and type II (not glycosylated at Asn-219). The single chain type I glycoform is less readily converted into the two-chain form by plasmin, and the two-chain type I glycoform has a lower activity than the two-chain type II glycoform in the presence of fibrin.; N-glycosylation of Asn-152; the bound oligomannosidic glycan is involved in the interaction with the mannose receptor.; Characterization of O-linked glycan was studied in Bowes melanoma cell line.

Protein cellular localization

Secreted, extracellular space.

Background

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Research area

All research areas>Signaling Intermediates>tPA
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize PLAT antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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