Rabbit polyclonal PLAU antibody (A2181)

$69.00$259.00

Reactivity: Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal PLAU antibody (A2181)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PLAU antibody.

Alternative names:

Check alternative names for the antibody

Expand

ATF antibody, UPA antibody, URK antibody, u-PA antibody
ATF antibody|ATF uPA antibody|BDPLT5 antibody|Plasminogen activator antibody|Plasminogen activator urinary antibody|Plasminogen activator urokinase antibody|PLAU antibody|QPD antibody|u PA antibody|U plasminogen activator antibody|u-PA antibody|U-plasminogen activator antibody|uPA antibody|URK antibody|UROK_HUMAN antibody|Urokinase plasminogen activator antibody|Urokinase type plasminogen activator antibody|Urokinase type plasminogen activator precursor antibody|Urokinase-type plasminogen activator chain B antibody|Anti-Urokinase antibody (ab24121)

SCBT cat No:

Name

Rabbit polyclonal PLAU antibody

Catalogue No.

A2181

Reactivity

Mouse, Rat

Immunogen

Recombinant protein of human PLAU

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 49kDa/Observed: Refer to Figures

Formulation

PLAU antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PLAU antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ATF antibody, UPA antibody, URK antibody, u-PA antibody

Database links

Human UniProt/Swiss-Prot:P00749

Protein names

ATF, UPA, URK, u-PA

Protein function

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

Protein tissue specificity

Expressed in the prostate gland and prostate cancers.

Protein sequence and domain

Belongs to the peptidase S1 family.; Contains 1 EGF-like domain.; Contains 1 kringle domain.; Contains 1 peptidase S1 domain.

Protein post-translational modifications

Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.

Protein cellular localization

Secreted.

Background

The human urokinase-type plasminogen activator receptor (uPAR) is a 55-65 kDa, highly glycosylated, GPI-anchored cell surface receptor (the deglycosylated protein is 35 kDa) (1-3). It is a central player in the plasminogen activation pathway. uPAR binds with high affinity to a serine protease urokinase-type plasminogen activator (uPA) and converts plasminogen to its active form plasmin in a spatially restricted manner on the cell surface (4). Plasmin further carries out the activation of uPA, which is inhibited by serpins, such as plasminogen activator inhibitors (5). Therefore, uPAR plays a key role in regulating extracellular proteolysis. In addition, uPAR plays an important role in regulating cell proliferation, adhesion, and mobility (6,7). Research studies have shown that overexpression of uPAR is found in various cancer cells and tissues (8,9).

Research area

All research areas>Signaling Intermediates>uPA
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize PLAU antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!