Rabbit polyclonal PLAUR antibody (A1397)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PLAUR antibody (A1397)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PLAUR antibody.

Alternative names:

Check alternative names for the antibody

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D87 antibody, UPAR antibody, URKR antibody
CD 87 antibody|CD87 antibody|CD87 antigen antibody|MO 3 antibody|MO3 antibody|Monocyte activation antigen Mo3 antibody|Plasminogen activator receptor urokinase antibody|Plasminogen activator urokinase receptor antibody|PLAUR antibody|U PAR antibody|u plasminogen activator receptor antibody|U-PAR antibody|u-plasminogen activator receptor form 2 antibody|UPA receptor antibody|uPAR antibody|UPAR_HUMAN antibody|Urinary plasminogen activator receptor antibody|URKR antibody|Urokinase plasminogen activator receptor antibody|Urokinase plasminogen activator surface receptor antibody|urokinase-type plasminogen activator (uPA) receptor antibody|Anti-uPA Receptor antibody (ab103791)

SCBT cat No:

Name

Rabbit polyclonal PLAUR antibody

Catalogue No.

A1397

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PLAUR

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 37kDa/Observed: Refer to Figures

Formulation

PLAUR antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PLAUR antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

D87 antibody, UPAR antibody, URKR antibody

Database links

Human UniProt/Swiss-Prot:Q03405

Protein names

D87, UPAR, URKR

Protein function

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

Protein tissue specificity

Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Protein sequence and domain

Contains 3 UPAR/Ly6 domains.

Protein cellular localization

Cell membrane . Cell projection, invadopodium membrane . Note: Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.; Isoform 1: Cell membrane ; Lipid-anchor, GPI-anchor .; Isoform 2: Secreted .

Background

Urokinase plasminogen activator surface receptor (uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator (uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)

Note

AntibodyPlus can customize PLAUR antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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