Rabbit polyclonal PLCG1 antibody (A7711)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PLCG1 antibody (A7711)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PLCG1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

PLC1 antibody, NCKAP3 antibody, PLC-II antibody, PLC148 antibody, PLCgamma1 antibody
1 phosphatidyl D myo inositol 4 5 bisphosphate antibody|1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 1 antibody|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 antibody|Inositoltrisphosphohydrolase antibody|Monophosphatidylinositol phosphodiesterase antibody|NCKAP3 antibody|Phosphatidylinositol phospholipase C antibody|Phosphoinositidase C antibody|Phosphoinositide phospholipase C antibody|Phosphoinositide phospholipase C-gamma-1 antibody|Phospholipase C 148 antibody|Phospholipase C gamma 1 antibody|Phospholipase C-gamma-1 antibody|Phospholipase C-II antibody|PLC gamma 1 antibody|PLC II antibody|PLC-148 antibody|PLC-gamma-1 antibody|PLC-II antibody|PLC1 antibody|PLC148 antibody|Plcg1 antibody|PLCG1_HUMAN antibody|PLCgamma1 antibody|Anti-Phospholipase C gamma 1 antibody [2B1] (ab16955)

SCBT cat No: sc-81|sc-58407|sc-426|sc-374467|sc-7290|sc-166938|sc-31748|sc-390389|sc-5283|sc-9015|sc-407|sc-131752|

Name

Rabbit polyclonal PLCG1 antibody

Catalogue No.

A7711

Reactivity

Human

Immunogen

A synthetic peptide of human PLCG1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 149kDa/Observed: Refer to figures

Formulation

PLCG1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PLCG1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PLC1 antibody, NCKAP3 antibody, PLC-II antibody, PLC148 antibody, PLCgamma1 antibody

Database links

Human UniProt/Swiss-Prot:P19174

Protein names

PLC1, NCKAP3, PLC-II, PLC148, PLCgamma1

Protein function

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.

Protein sequence and domain

The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1.Contains 1 C2 domain.; Contains 1 EF-hand domain.; Contains 2 PH domains.; Contains 1 PI-PLC X-box domain.; Contains 1 PI-PLC Y-box domain.; Contains 2 SH2 domains.; Contains 1 SH3 domain.

Protein post-translational modifications

Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity). Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells.; Ubiquitinated by CBLB in activated T-cells.

Protein cellular localization

Cell projection, lamellipodium. Cell projection, ruffle. Note: Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.

Background

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Synthesis and Degradation>PLC
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize PLCG1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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