Rabbit polyclonal PLCG2 antibody (A2182)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal PLCG2 antibody (A2182)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:20 – 1:100 IP 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PLCG2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

PLCG2 antibody,APLAID antibody,FCAS3 antibody
1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2 antibody|1-phosphatidylinositol-4 antibody|5-bisphosphate phosphodiesterase gamma-2 antibody|EC 3.1.4.11 antibody|Phosphoinositide phospholipase C antibody|Phosphoinositide phospholipase C-gamma-2 antibody|Phospholipase C gamma 2 antibody|Phospholipase C, gamma 2 (phosphatidylinositol specific) antibody|Phospholipase C-gamma-2 antibody|Phospholipase C-IV antibody|PLC 2 antibody|PLC gamma 2 antibody|PLC IV antibody|PLC-gamma-2 antibody|PLC-IV antibody|Plcg2 antibody|PLCG2_HUMAN antibody|Phospho anti-PLCG 2 (Y753) antibody (ab75659)

SCBT cat No: sc-390389|sc-5283|sc-9015|sc-407|sc-131752|

Name

Rabbit polyclonal PLCG2 antibody

Catalogue No.

A2182

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PLCG2

Host

Rabbit

Applications

WB, IHC, IF, IP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:20 – 1:100
IP 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 150kDa/Observed: Refer to Figures

Formulation

PLCG2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PLCG2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PLCG2 antibody,APLAID antibody,FCAS3 antibody

Database links

Human UniProt/Swiss-Prot:P16885

Protein names

PLCG2,APLAID,FCAS3

Protein function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

Protein sequence and domain

Contains 1 C2 domain.; Contains 1 PH domain.; Contains 1 PI-PLC X-box domain.; Contains 1 PI-PLC Y-box domain.; Contains 2 SH2 domains.; Contains 1 SH3 domain.

Protein post-translational modifications

Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.

Background

Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG) (1). At least four families of PLCs have been identified: PLCbeta, PLCgamma, PLCdelta and PLCepsilon. The PLCbeta subfamily includes four members, PLCbeta1-4. All four members of the subfamily are activated by alpha- or beta-gamma-subunits of the heterotrimeric G-proteins (2,3).Phosphorylation is one of the key mechanisms that regulates the activity of PLC. Phosphorylation of Ser1105 by PKA or PKC inhibits PLCbeta3 activity (4,5). Ser537 of PLCbeta3 is phosphorylated by CaMKII, and this phosphorylation may contribute to the basal activity of PLCbeta3. PLCgamma is activated by both receptor and nonreceptor tyrosine kinases (6).PLCgamma forms a complex with EGF and PDGF receptors, which leads to the phosphorylation of PLCgamma at Tyr771, 783 and 1245 (7). Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLCgamma1 (8).PLCgamma2 is engaged in antigen-dependent signaling in B cells and collagen-dependent signaling in platelets. Phosphorylation by Btk or Lck at Tyr753, 759, 1197 and 1217 is correlated with PLCgamma2 activity (9,10

Research area

All research areas>Synthesis and Degradation>PLC
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize PLCG2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!