Rabbit polyclonal PLG antibody (A3320)

$69.00$259.00

Reactivity: Human,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PLG antibody (A3320)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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Angiostatin antibody|DKFZp779M0222 antibody|Plasmin antibody|Plasmin heavy chain A antibody|Plasmin light chain B antibody|Plasminogen antibody|PLG antibody|PLMN_HUMAN antibody|Anti-Plasminogen antibody (ab154560)

SCBT cat No: sc-15036|

Name

Rabbit polyclonal PLG antibody

Catalogue No.

A3320

Reactivity

Human, Rat

Immunogen

Recombinant protein of human PLG

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 91kDa/Observed: Refer to Figures

Formulation

PLG antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PLG antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:P00747

Protein function

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.; Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.

Protein tissue specificity

Present in plasma and many other extracellular fluids. It is synthesized in the liver.

Protein sequence and domain

Kringle domains mediate interaction with CSPG4.Belongs to the peptidase S1 family. Plasminogen subfamily.; Contains 5 kringle domains.; Contains 1 PAN domain.; Contains 1 peptidase S1 domain.

Protein post-translational modifications

N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).; In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.

Protein cellular localization

Secreted . Note: Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.

Background

The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Signaling Intermediates>plasminogen
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize PLG antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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