Rabbit polyclonal PLK4 antibody (A9863)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PLK4 antibody (A9863)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PLK 4 antibody|PLK-4 antibody|PLK4 antibody|PLK4_HUMAN antibody|Polo like Kinase 4 antibody|Polo-like kinase 4 antibody|Protein serine/threonine kinase antibody|SAK antibody|Serine/Threonine Kinase 18 antibody|Serine/threonine kinase antibody|Serine/threonine protein kinase 18 antibody|Serine/threonine protein kinase PLK4 antibody|Serine/threonine protein kinase Sak antibody|Serine/threonine-protein kinase 18 antibody|Serine/threonine-protein kinase PLK4 antibody|Serine/threonine-protein kinase SAK antibody|Snk Akin Kinase antibody|STK 18 antibody|STK18 antibody|Anti-PLK4 antibody (ab71394)

SCBT cat No: sc-100413|sc-98929|

Name

Rabbit polyclonal PLK4 antibody

Catalogue No.

A9863

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PLK4

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 109kDa/Observed: Refer to figures

Formulation

PLK4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PLK4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:O00444

Protein function

Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates ‘Ser-151’ of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification .

Protein sequence and domain

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.; Contains 1 POLO box domain.; Contains 1 protein kinase domain.

Protein post-translational modifications

Ubiquitinated; leading to its degradation by the proteasome.; Tyrosine-phosphorylated by TEC.

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Nucleus, nucleolus . Cleavage furrow. Note: Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.

Background

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Note

AntibodyPlus can customize PLK4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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