Rabbit polyclonal PMS2 antibody (A6947)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PMS2 antibody (A6947)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PMSL2 antibody, HNPCC4 antibody, PMS2CL antibody
DNA mismatch repair gene homologue antibody|DNA mismatch repair protein PMS2 antibody|H_DJ0042M02.9 antibody|HNPCC4 antibody|Mismatch repair endonuclease PMS2 antibody|Mismatch repair gene PMSL2 antibody|PMS 2 antibody|PMS1 protein homolog 2 antibody|PMS2 antibody|PMS2 postmeiotic segregation increased 2 antibody|PMS2 postmeiotic segregation increased 2 (S. cerevisiae) antibody|PMS2_HUMAN antibody|PMS2CL antibody|PMSL2 antibody|Postmeiotic segregation increased, S. cerevisiae, 2 antibody|Anti-PMS2 antibody [EPR3947] (ab110638)

SCBT cat No: sc-25315|sc-618|sc-617|sc-11440|

Name

Rabbit polyclonal PMS2 antibody

Catalogue No.

A6947

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PMS2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 96kDa/Observed: Refer to figures

Formulation

PMS2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PMS2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PMSL2 antibody, HNPCC4 antibody, PMS2CL antibody

Database links

Human UniProt/Swiss-Prot:P54278

Protein names

PMSL2, HNPCC4, PMS2CL

Protein function

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages.

Protein sequence and domain

Belongs to the DNA mismatch repair MutL/HexB family.

Protein cellular localization

Nucleus .

Background

This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Research area

All research areas>Tumor Suppressor/Apoptosis>PMS
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize PMS2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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