Rabbit polyclonal PNKP antibody (A6693)

$69.00$259.00

Reactivity: Human,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PNKP antibody (A6693)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PNK antibody, MCSZ antibody, EIEE10 antibody
2”(3”)-polynucleotidase antibody|2′(3′)-polynucleotidase antibody|Bifunctional polynucleotide phosphatase/kinase antibody|DEM 1 antibody|DEM1 antibody|DNA 5′ kinase/3′ phosphatase antibody|DNA 5”-kinase/3”-phosphatase antibody|EIEE10 antibody|Homo sapiens polynucleotide kinase 3′ phosphatase (PNKP) antibody|MCSZ antibody|PNK 1 antibody|PNK1 antibody|Pnkp antibody|PNKP DNA kinase antibody|PNKP_HUMAN antibody|Polynucleotide 3′-phosphatase antibody|Polynucleotide 5′ hydroxyl kinase antibody|Polynucleotide 5”-hydroxyl-kinase antibody|Polynucleotide kinase 3 prime phosphatase antibody|Polynucleotide kinase 3′ phosphatase antibody|Polynucleotide Kinase antibody|Polynucleotide kinase-3”-phosphatase antibody|Anti-PNK antibody [EPR11934(B)] (ab170954)

SCBT cat No: sc-271525|sc-166188|sc-365724|sc-166080|sc-271135|sc-271505|sc-166153|

Name

Rabbit polyclonal PNKP antibody

Catalogue No.

A6693

Reactivity

Human, Rat

Immunogen

Recombinant protein of human PNKP

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 57kDa/Observed: Refer to figures

Formulation

PNKP antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PNKP antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PNK antibody, MCSZ antibody, EIEE10 antibody

Database links

Human UniProt/Swiss-Prot:Q96T60

Protein names

PNK, MCSZ, EIEE10

Protein function

Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3′-phosphates from, or by phosphorylating 5′-hydroxyl groups on, the ribose sugar of the DNA backbone.

Protein tissue specificity

Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine . Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver .

Protein sequence and domain

The FHA domain binds threonine-phosphorylated peptides from XRCC1/4, and is responsible for the recruitment of PNKP to the sites of DNA repair. The affinity is ten times greater if peptides are also phosphorylated on the serine preceeding the phosphothreonine.In the N-terminal section; belongs to the DNA 3′ phosphatase family.; Contains 1 FHA domain.

Protein cellular localization

Nucleus .

Background

This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5′ phosphorylation and 3′ dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.

Note

AntibodyPlus can customize PNKP antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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