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Rabbit polyclonal POLB antibody (A1681)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:200 – 1:1000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal POLB antibody.
Check alternative names for the antibodyExpand
MGC125976 antibody, POLB antibody
DNA directed DNA polymerase beta antibody|DNA pol beta antibody|DNA polymerase beta antibody|DNA polymerase beta subunit antibody|DPOLB_HUMAN antibody|MGC125976 antibody|Pol B antibody|Pol beta antibody|POLB antibody|Polymerase (DNA directed) beta antibody|Anti-DNA Polymerase beta antibody (ab26343)
SCBT cat No: sc-376581|sc-48819|sc-5927|sc-5925|
Rabbit polyclonal POLB antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human POLB
WB, IHC, IF
|Recommended dilution|| |
WB 1:200 – 1:1000
|Molecular weight|| |
Predicted: 38kDa/Observed: Refer to Figures
POLB antibody was tube-contained.
POLB antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
MGC125976 antibody, POLB antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Repair polymerase that plays a key role in base-excision repair. Has 5′-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5′ sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3′ end of the arising single-nucleotide gap. Conducts ‘gap-filling’ DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
|Protein sequence and domain|| |
Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.Belongs to the DNA polymerase type-X family.
|Protein post-translational modifications|| |
Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.; Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1. Monoubiquitinated protein is then the target of STUB1/CHIP, which catalyzes polyubiquitination from monoubiquitin, leading to degradation by the proteasome. USP47 mediates the deubiquitination of monoubiquitinated protein, preventing polyubiquitination by STUB1/CHIP and its subsequent degradation.
|Protein cellular localization|| |
Nucleus. Cytoplasm. Note: Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
AntibodyPlus can customize POLB antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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