Rabbit polyclonal PPAP2A antibody (A3062)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PPAP2A antibody (A3062)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PPAP2A antibody.

Alternative names:

Check alternative names for the antibody

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LPP1 antibody, PAP2 antibody, LLP1a antibody, PAP-2a antibody
Lipid phosphate phosphohydrolase 1 antibody|Lipid phosphate phosphohydrolase 1a antibody|LLP1a antibody|LPP1 antibody|LPP1_HUMAN antibody|PAP 2a antibody|PAP-2a antibody|PAP2 antibody|PAP2-alpha antibody|PAP2a antibody|PAP2a2 antibody|PAP2alpha2 antibody|PAPalpha1 antibody|Phosphatidate phosphohydrolase type 2a antibody|Phosphatidic acid phosphatase 2a antibody|Phosphatidic acid phosphatase type 2A antibody|Phosphatidic acid phosphohydrolase type 2a antibody|PPAP2A antibody|Type 2 phosphatidic acid phosphatase alpha antibody|Type 2 phosphatidic acid phosphohydrolase antibody|Anti-PPAP2A antibody (ab58745)

SCBT cat No: sc-133882|sc-515517|

Name

Rabbit polyclonal PPAP2A antibody

Catalogue No.

A3062

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human PPAP2A

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 32kDa/Observed: Refer to figures

Formulation

PPAP2A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PPAP2A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LPP1 antibody, PAP2 antibody, LLP1a antibody, PAP-2a antibody

Database links

Human UniProt/Swiss-Prot:O14494

Protein names

LPP1, PAP2, LLP1a, PAP-2a

Protein function

Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It’s down-regulation may contribute to the development of colon adenocarcinoma.

Protein tissue specificity

Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas.

Protein sequence and domain

Belongs to the PA-phosphatase related phosphoesterase family.

Protein post-translational modifications

N-glycosylated. Contains high-mannose oligosaccharides.

Protein cellular localization

Cell membrane; Multi-pass membrane protein.

Background

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene.

Note

AntibodyPlus can customize PPAP2A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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