Rabbit polyclonal PPIA antibody (A0993)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PPIA antibody (A0993)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PPIA antibody,CYPA antibody,CYPH antibody,MGC117158 antibody,MGC12404 antibody,MGC23397 antibody
Cyclophilin A antibody|Cyclophilin antibody|CyclophilinA antibody|Cyclosporin A binding protein antibody|Cyclosporin A-binding protein antibody|CYPA antibody|CYPH antibody|Epididymis secretory sperm binding protein Li 69p antibody|HEL S 69p antibody|MGC117158 antibody|MGC12404 antibody|MGC23397 antibody|Peptidyl prolyl cis trans isomerase A antibody|Peptidyl-prolyl cis-trans isomerase A antibody|Peptidylprolyl isomerase A (cyclophilin A) antibody|Peptidylprolyl isomerase A antibody|PPIA antibody|PPIA protein antibody|PPIA_HUMAN antibody|PPIase A antibody|Rotamase A antibody|RotamaseA antibody|T cell cyclophilin antibody|Anti-Cyclophilin A antibody (ab41684)

SCBT cat No: sc-134310|sc-20360|

Name

Rabbit polyclonal PPIA antibody

Catalogue No.

A0993

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PPIA

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 18kDa/Observed: Refer to Figures

Formulation

PPIA antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PPIA antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PPIA antibody,CYPA antibody,CYPH antibody,MGC117158 antibody,MGC12404 antibody,MGC23397 antibody

Database links

Human UniProt/Swiss-Prot:P62937

Protein names

PPIA,CYPA,CYPH,MGC117158,MGC12404,MGC23397

Protein function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Protein sequence and domain

Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.; Contains 1 PPIase cyclophilin-type domain.

Protein post-translational modifications

Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.

Protein cellular localization

Cytoplasm . Secreted . Note: Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.

Background

Cyclophilins are a highly conserved family of peptidylprolyl cis-trans-isomerases (PPIA) that are targets of the immunosuppressant drug cyclosporin A (CsA) (1,2). The complex of cyclophilin and CsA can bind to and inhibit calcineurin which leads to inhibition of the transcription factor NFAT and decreased production of cytokines (3,4). As isomerases, cyclophilins have been proposed to aid in protein folding. Cyclophilin A can bind to the p55 Gag protein of HIV and appears necessary for HIV infection (5,6). There is also some evidence that cyclophilins have nuclease activity and play a role in apoptosis (7).

Research area

All research areas>Signaling Intermediates>Cyclophilin
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize PPIA antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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