Rabbit polyclonal PPL antibody (A6950)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PPL antibody (A6950)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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190 kDa paraneoplastic pemphigus antigen antibody|195 kDa cornified envelope precursor antibody|195 kDa cornified envelope precursor protein antibody|AW553870 antibody|KIAA0568 antibody|MGC134872 antibody|PEPL_HUMAN antibody|Periplakin antibody|ppl antibody|Anti-Periplakin antibody (ab72422)

SCBT cat No: sc-80605|sc-16754|sc-365530|sc-50449|

Name

Rabbit polyclonal PPL antibody

Catalogue No.

A6950

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PPL

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 205kDa/Observed: Refer to figures

Formulation

PPL antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PPL antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:O60437

Protein function

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.

Protein tissue specificity

Expressed in stratified squamous epithelia and in some other epithelia.

Protein sequence and domain

Belongs to the plakin or cytolinker family.; Contains 2 plectin repeats.; Contains 4 spectrin repeats.

Protein cellular localization

Cell junction, desmosome . Cytoplasm, cytoskeleton . Cell membrane . Nucleus . Mitochondrion . Note: Associated with desmosomes and intermediate filaments.

Background

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.

Note

AntibodyPlus can customize PPL antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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