Rabbit polyclonal PPM1A antibody (A6699)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PPM1A antibody (A6699)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PPM1A antibody.

Alternative names:

Check alternative names for the antibody

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PP2CA antibody, PP2Calpha antibody, PP2C-ALPHA antibody
Protein phosphatase 2C isoform alpha antibody|EC 3.1.3.16 antibody|FLJ42306 antibody|IA antibody|MGC9201 antibody|Mpp alpha antibody|PP2C alpha antibody|PP2C-alpha antibody|PP2CA antibody|PP2Calpha antibody|PPM 1A antibody|PPM1A antibody|PPM1A_HUMAN antibody|PPPM1A antibody|Protein phosphatase 1A (formerly 2C) magnesium dependent alpha isoform antibody|Protein phosphatase 1A antibody|Protein phosphatase 1A magnesium dependent alpha antibody|Protein phosphatase 2C alpha antibody|Protein phosphatase 2C alpha isoform antibody|Protein phosphatase 2C isoform alpha antibody|Protein phosphatase IA antibody|Protein phosphatase, Mg2+/Mn2+ dependent, 1A antibody|Anti-PPM1A antibody [p6c7] (ab14824)

SCBT cat No: sc-71922|sc-32402|sc-56956|sc-166662|sc-48829|

Name

Rabbit polyclonal PPM1A antibody

Catalogue No.

A6699

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PPM1A

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 42kDa/Observed: Refer to figures

Formulation

PPM1A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PPM1A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PP2CA antibody, PP2Calpha antibody, PP2C-ALPHA antibody

Database links

Human UniProt/Swiss-Prot:P35813

Protein names

PP2CA, PP2Calpha, PP2C-ALPHA

Protein function

Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Protein sequence and domain

Belongs to the PP2C family.; Contains 1 PPM-type phosphatase domain.

Protein post-translational modifications

N-myristoylation is essential for the recognition of its substrates for dephosphorylation.

Protein cellular localization

Nucleus . Cytoplasm, cytosol . Membrane ; Lipid-anchor . Note: Weakly associates at the membrane and N-myristoylation mediates the membrane localization.

Background

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Research area

All research areas>Kinases and Phosphatases>PP2
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize PPM1A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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