Rabbit polyclonal PPP1CA antibody (A2184)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal PPP1CA antibody (A2184)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PPP1CA antibody.

Alternative names:

Check alternative names for the antibody

Expand

PPP1CA antibody,MGC15877 antibody,MGC1674 antibody,PP-1A antibody,PP1alpha antibody,PPP1A antibody
PP-1A antibody|PP-1B antibody|PP1A antibody|PP1alpha antibody|PP1B antibody|PP1beta antibody|PPP1A antibody|PPP1CD antibody|protein phosphatase 1 catalytic subunit alpha isozyme antibody|protein phosphatase 1 catalytic subunit beta isoform antibody|protein phosphatase 1 catalytic subunit delta isoform antibody|serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit antibody|Serine/threonine-protein phosphatase PP1-alpha catalytic subunit antibody|Serine/threonine-protein phosphatase PP1-beta catalytic subunit antibody|Anti-PPP1CA + 1CB antibody [EP1511Y] (ab52619)

SCBT cat No: sc-517233|sc-365678|sc-6106|sc-373782|sc-377125|sc-373783|sc-6107|

Name

Rabbit polyclonal PPP1CA antibody

Catalogue No.

A2184

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PPP1CA

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 38kDa/Observed: Refer to Figures

Formulation

PPP1CA antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PPP1CA antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PPP1CA antibody,MGC15877 antibody,MGC1674 antibody,PP-1A antibody,PP1alpha antibody,PPP1A antibody

Database links

Human UniProt/Swiss-Prot:P62136

Protein names

PPP1CA,MGC15877,MGC1674,PP-1A,PP1alpha,PPP1A

Protein function

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the ‘Ser-418’ residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective .

Protein sequence and domain

Belongs to the PPP phosphatase family. PP-1 subfamily.

Protein post-translational modifications

Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation.

Protein cellular localization

Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note: Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.

Background

Type 1 protein phosphatase (PP1), a serine/threonine phosphatase, is highly conserved in eukaryotic cells. Four isoforms of PP1 have been characterized: PP1alpha, PP1delta, PP1gamma1 and PP1gamma2 (1). Involvement in cell cycle regulation is one of the biological functions of PP1 (1). It has been illustrated that PP1 dephosphorylates Rb and cdc25 during mitosis (2,3). A cell cycle-dependent phosphorylation at Thr320 of PP1alpha by cdc2 kinase inhibits PP1alpha activity (4).

Research area

All research areas>Kinases and Phosphatases>PP1
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize PPP1CA antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!