Rabbit polyclonal PPP1R8 antibody (A6701)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PPP1R8 antibody (A6701)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PPP1R8 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ARD1 antibody, ARD-1 antibody, NIPP1 antibody, NIPP-1 antibody, PRO2047 antibody
Activator of RNA decay antibody|ARD 1 antibody|ARD-1 antibody|ARD1 antibody|Homolog of E.coli RNase E antibody|NIPP 1 antibody|NIPP-1 antibody|NIPP1 antibody|Nuclear inhibitor of protein phosphatase 1 antibody|nuclear inhibitor of protein phosphatase-1 alpha antibody|Nuclear subunit of PP1 antibody|PP1R8_HUMAN antibody|PPP1R8 antibody|PRO2047 antibody|Protein phosphatase 1 regulatory inhibitor subunit 8 antibody|Protein phosphatase 1 regulatory subunit 8 antibody|RNase E antibody|RNase E, E. coli, homolog of antibody|Anti-NIPP1 antibody (ab129286)

SCBT cat No: sc-136425|sc-393991|sc-271749|

Name

Rabbit polyclonal PPP1R8 antibody

Catalogue No.

A6701

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PPP1R8

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 38kDa/Observed: Refer to figures

Formulation

PPP1R8 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PPP1R8 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ARD1 antibody, ARD-1 antibody, NIPP1 antibody, NIPP-1 antibody, PRO2047 antibody

Database links

Human UniProt/Swiss-Prot:Q12972

Protein names

ARD1, ARD-1, NIPP1, NIPP-1, PRO2047

Protein function

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.; Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3′ to purines and pyrimidines in A+U-rich regions. It generates 5′-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.

Protein tissue specificity

Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells.

Protein sequence and domain

Has a basic N- and C-terminal and an acidic central domain.; The FHA domain mediates interactions with threonine-phosphorylated MELK.Contains 1 FHA domain.

Protein post-translational modifications

May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity). Phosphorylated by Lyn in vitro on Tyr-264, and also on Tyr-335 in the presence of RNA.

Protein cellular localization

Nucleus. Nucleus speckle. Note: Primarily, but not exclusively, nuclear.; Isoform Gamma: Cytoplasm. Note: Found mainly in the cytoplasm.

Background

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.

Research area

All research areas>Transcription Regulators>NIPP
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize PPP1R8 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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