Rabbit polyclonal PPP4C antibody (A2109)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal PPP4C antibody (A2109)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PPP4C antibody.

Alternative names:

Check alternative names for the antibody

Expand

PP4 antibody, PPX antibody, PP4C antibody, PPH3 antibody, PPP4 antibody
PP X antibody|PP-X antibody|Pp4 antibody|PP4C antibody|PP4C_HUMAN antibody|PPH3 antibody|PPP4 antibody|ppp4c antibody|PPX antibody|protein phosphatase 4 (formerly X), catalytic subunit antibody|Protein phosphatase 4 catalytic subunit antibody|Protein phosphatase X antibody|protein phosphatase X, catalytic subunit antibody|Serine/threonine protein phosphatase 4 catalytic subunit antibody|Serine/threonine-protein phosphatase 4 catalytic subunit antibody|Anti-PPP4C antibody [EPR19502] (ab195371)

SCBT cat No: sc-6118|sc-374106|

Name

Rabbit polyclonal PPP4C antibody

Catalogue No.

A2109

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PPP4C

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 35kDa/Observed: Refer to Figures

Formulation

PPP4C antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PPP4C antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PP4 antibody, PPX antibody, PP4C antibody, PPH3 antibody, PPP4 antibody

Database links

Human UniProt/Swiss-Prot:P60510

Protein names

PP4, PPX, PP4C, PPH3, PPP4

Protein function

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Protein sequence and domain

Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Protein post-translational modifications

Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.

Protein cellular localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Background

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family.

Research area

All research areas>Kinases and Phosphatases>PPX
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize PPP4C antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!