Rabbit polyclonal PQBP1 antibody (A4369)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PQBP1 antibody (A4369)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:200 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PQBP1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

SHS antibody, MRX2 antibody, MRX55 antibody, MRXS3 antibody, MRXS8 antibody, NPW38 antibody, RENS1 antibody
38 kDa nuclear protein containing a WW domain antibody|Mental retardation, X linked 55 antibody|MRX55 antibody|MRXS3 antibody|MRXS8 antibody|Npw38 antibody|Nuclear protein containing WW domain 38 kD antibody|OTTHUMP00000025808 antibody|Polyglutamine binding protein 1 antibody|Polyglutamine tract binding protein 1 antibody|Polyglutamine tract-binding protein 1 antibody|Polyglutamine-binding protein 1 antibody|PQBP 1 antibody|PQBP-1 antibody|PQBP1 antibody|PQBP1_HUMAN antibody|RENS1 antibody|SHS antibody|Sutherland Haan X linked mental retardation syndrome antibody|Anti-PQBP1 antibody (ab100797)

SCBT cat No: sc-374260|sc-26054|sc-32910|sc-376039|sc-26052|

Name

Rabbit polyclonal PQBP1 antibody

Catalogue No.

A4369

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PQBP1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:200 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 30kDa/Observed: Refer to figures

Formulation

PQBP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PQBP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SHS antibody, MRX2 antibody, MRX55 antibody, MRXS3 antibody, MRXS8 antibody, NPW38 antibody, RENS1 antibody

Database links

Human UniProt/Swiss-Prot:O60828

Protein names

SHS, MRX2, MRX55, MRXS3, MRXS8, NPW38, RENS1

Protein function

Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species . May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.

Protein tissue specificity

Widely expressed with high level in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes.

Protein sequence and domain

The WW domain may play a role as a transcriptional activator directly or via association with the transcription machinery. The WW domain mediates interaction with WBP11, ATN1, SF3B1 and the C-terminal domain of the RNA polymerase II large subunit.; Except for the WW domain, the protein is intrinsically disordered.Contains 1 WW domain.

Protein cellular localization

Nucleus . Nucleus speckle . Note: Colocalizes with SRSF2 in nuclear speckles (By similarity). Colocalized with POU3F2. Colocalized with ATXN1 in nuclear inclusion bodies.

Background

This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Note

AntibodyPlus can customize PQBP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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