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Rabbit polyclonal PRKACB antibody (A5324)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal PRKACB antibody.
Check alternative names for the antibodyExpand
cAMP-dependent protein kinase catalytic beta subunit isoform 4ab antibody|cAMP-dependent protein kinase catalytic subunit beta antibody|KAPCB_HUMAN antibody|PKA C beta antibody|PKA C-beta antibody|PKACB antibody|Prkacb antibody|protein kinase A catalytic subunit beta antibody|Protein kinase cAMP dependent catalytic beta antibody|Anti-PKA beta (catalytic subunit) antibody (ab187515)
SCBT cat No: sc-904|sc-30665|
Rabbit polyclonal PRKACB antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human PRKACB
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 40kDa/Observed: Refer to Figures
PRKACB antibody was tube-contained.
PRKACB antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
|Protein tissue specificity|| |
Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.; Contains 1 AGC-kinase C-terminal domain.; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.
|Protein cellular localization|| |
Cytoplasm . Cell membrane . Membrane ; Lipid-anchor . Nucleus . Note: Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.
AntibodyPlus can customize PRKACB antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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