Rabbit polyclonal PRKACB antibody (A5324)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PRKACB antibody (A5324)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PKACB antibody
cAMP-dependent protein kinase catalytic beta subunit isoform 4ab antibody|cAMP-dependent protein kinase catalytic subunit beta antibody|KAPCB_HUMAN antibody|PKA C beta antibody|PKA C-beta antibody|PKACB antibody|Prkacb antibody|protein kinase A catalytic subunit beta antibody|Protein kinase cAMP dependent catalytic beta antibody|Anti-PKA beta (catalytic subunit) antibody (ab187515)

SCBT cat No: sc-904|sc-30665|

Name

Rabbit polyclonal PRKACB antibody

Catalogue No.

A5324

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PRKACB

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 40kDa/Observed: Refer to Figures

Formulation

PRKACB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PRKACB antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PKACB antibody

Database links

Human UniProt/Swiss-Prot:P22694

Protein names

PKACB

Protein function

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.

Protein tissue specificity

Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.

Protein sequence and domain

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.; Contains 1 AGC-kinase C-terminal domain.; Contains 1 protein kinase domain.

Protein post-translational modifications

Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.

Protein cellular localization

Cytoplasm . Cell membrane . Membrane ; Lipid-anchor . Nucleus . Note: Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm.

Background

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.

Research area

All research areas>Kinases and Phosphatases>PKA
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize PRKACB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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