Rabbit polyclonal PRKAR1A antibody (A0906)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PRKAR1A antibody (A0906)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PRKAR1A antibody.

Alternative names:

Check alternative names for the antibody

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PRKAR1A antibody,CAR antibody,CNC antibody,CNC1 antibody,DKFZp779L0468 antibody,MGC17251 antibody,PKR1 antibody,PPNAD1 antibody,PRKAR1 antibody,TSE1 antibody
ACRDYS1 antibody|ADOHR antibody|cAMP dependent protein kinase regulatory subunit alpha 1 antibody|cAMP dependent protein kinase regulatory subunit RIalpha antibody|cAMP dependent protein kinase type I alpha regulatory chain antibody|cAMP dependent protein kinase type I alpha regulatory subunit antibody|cAMP-dependent protein kinase type I-alpha regulatory subunit antibody|CAR antibody|Carney complex type 1 antibody|CNC 1 antibody|CNC antibody|CNC1 antibody|DKFZp779L0468 antibody|KAP0_HUMAN antibody|MGC17251 antibody|PKA RIA antibody|PKR 1 antibody|PKR1 antibody|PPNAD 1 antibody|PPNAD1 antibody|PRKAR 1 antibody|PRKAR1 antibody|PRKAR1A antibody|PRKAR1A/RARA FUSION GENE antibody|Protein kinase A type 1a regulatory subunit antibody|Protein kinase cAMP dependent regulatory type I alpha antibody|PTC2 CHIMERIC ONCOGENE, INCLUDED antibody|Tissue specific extinguisher 1 antibody|Tissue-specific extinguisher 1 antibody|TSE 1 antibody|TSE1 antibody|Phospho anti-Protein Kinase A regulatory subunit I alpha (S83) antibody [EPMAYR1] (ab154851)

SCBT cat No: sc-136231|sc-18800|sc-18798|sc-271125|sc-271446|sc-28893|

Name

Rabbit polyclonal PRKAR1A antibody

Catalogue No.

A0906

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PRKAR1A

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 43kDa/Observed: Refer to Figures

Formulation

PRKAR1A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PRKAR1A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PRKAR1A antibody,CAR antibody,CNC antibody,CNC1 antibody,DKFZp779L0468 antibody,MGC17251 antibody,PKR1 antibody,PPNAD1 antibody,PRKAR1 antibody,TSE1 antibody

Database links

Human UniProt/Swiss-Prot:P10644

Protein names

PRKAR1A,CAR,CNC,CNC1,DKFZp779L0468,MGC17251,PKR1,PPNAD1,PRKAR1,TSE1

Protein function

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.

Protein tissue specificity

Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

Protein sequence and domain

Belongs to the cAMP-dependent kinase regulatory chain family.; Contains 2 cyclic nucleotide-binding domains.

Protein post-translational modifications

The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.

Protein cellular localization

Cell membrane .

Background

The second messenger cyclic AMP (cAMP) activates cAMP-dependent protein kinase (PKA or cAPK) in mammalian cells and controls many cellular mechanisms such as gene transcription, ion transport, and protein phosphorylation (1). Inactive PKA is a heterotetramer composed of a regulatory subunit (R) dimer and a catalytic subunit (C) dimer. In this inactive state, the pseudosubstrate sequences on the R subunits block the active sites on the C subunits. Three C subunit isoforms (C-alpha, C-beta, and C-gamma) and two families of regulatory subunits (RI and RII) with distinct cAMP binding properties have been identified. The two R families exist in two isoforms, alpha and beta (RI-alpha, RI-beta, RII-alpha, and RII-beta). Upon binding of cAMP to the R subunits, the autoinhibitory contact is eased and active monomeric C subunits are released. PKA shares substrate specificity with Akt (PKB) and PKC, which are characterized by an arginine at position -3 relative to the phosphorylated serine or threonine residue (2). Substrates that present this consensus sequence and have been shown to be phosphorylated by PKA are Bad (Ser155), CREB (Ser133), and GSK-3 (GSK-3alpha Ser21 and GSK-3beta Ser9) (3-5). In addition, combined knock-down of PKA C-alpha and -beta blocks cAMP-mediated phosphorylation of Raf (Ser43 and Ser259) (6). Autophosphorylation and phosphorylation by PDK-1 are two known mechanisms responsible for phosphorylation of the C subunit at Thr197 (7).

Research area

All research areas>Kinases and Phosphatases>PKA
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize PRKAR1A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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