Rabbit polyclonal PRKRA antibody (A5417)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PRKRA antibody (A5417)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

RAX antibody, PACT antibody, DYT16 antibody, HSD14 antibody
DYT16 antibody|HSD14 antibody|Interferon inducible double stranded RNA dependent protein kinase activator A antibody|interferon-inducible double stranded RNA-dependent activator antibody|Interferon-inducible double stranded RNA-dependent protein kinase activator A antibody|PACT antibody|PKR associated protein X antibody|PKR associating protein X antibody|PKR-associated protein X antibody|PKR-associating protein X antibody|PRKRA antibody|PRKRA_HUMAN antibody|Protein activator of the interferon induced protein kinase antibody|Protein activator of the interferon-induced protein kinase antibody|Protein kinase antibody|Protein kinase interferon inducible double stranded RNA dependent activator antibody|RAX antibody|Anti-PACT (PKR activating protein) / PRKRA antibody (ab31967)

SCBT cat No: sc-73478|sc-53524|

Name

Rabbit polyclonal PRKRA antibody

Catalogue No.

A5417

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PRKRA

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 34kDa/Observed: Refer to Figures

Formulation

PRKRA antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PRKRA antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RAX antibody, PACT antibody, DYT16 antibody, HSD14 antibody

Database links

Human UniProt/Swiss-Prot:O75569

Protein names

RAX, PACT, DYT16, HSD14

Protein function

Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at ‘Lys-386’ at ‘Ser-392’ respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

Protein sequence and domain

Self-association may occur via interactions between DRBM domains as follows: DRBM 1/DRBM 1, DRBM 1/DRBM 2, DRBM 2/DRBM 2 or DRBM 3/DRBM3.Belongs to the PRKRA family.; Contains 3 DRBM (double-stranded RNA-binding) domains.

Protein post-translational modifications

Phosphorylated at Ser-246 in unstressed cells and at Ser-287 in stressed cells. Phosphorylation at Ser-246 appears to be a prerequisite for subsequent phosphorylation at Ser-287. Phosphorylation at Ser-246 and Ser-287 are necessary for activation of EIF2AK2/PKR under conditions of stress.

Protein cellular localization

Cytoplasm, perinuclear region. Cytoplasm.

Background

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants.

Note

AntibodyPlus can customize PRKRA antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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