Rabbit polyclonal PSEN2 antibody (A7719)

$69.00$259.00

Reactivity: Human,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PSEN2 antibody (A7719)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

AD4 antibody, PS2 antibody, AD3L antibody, STM2 antibody, CMD1V antibody
AD3L antibody|AD3LP antibody|AD4 antibody|AD5 antibody|Alzheimer disease 4 antibody|CMD1V antibody|E5-1 antibody|OTTHUMP00000035671 antibody|OTTHUMP00000035672 antibody|OTTHUMP00000228286 antibody|OTTHUMP00000228288 antibody|Presenilin 2 (Alzheimer disease 4) antibody|Presenilin 2 antibody|Presenilin-2 CTF subunit antibody|PS-2 antibody|PS2 antibody|Psen2 antibody|PSN2_HUMAN antibody|PSNL2 antibody|STM-2 antibody|STM2 antibody|Anti-Presenilin 2 antibody [EP1515Y] (ab51249)

SCBT cat No: sc-393758|sc-1456|sc-7861|sc-1457|

Name

Rabbit polyclonal PSEN2 antibody

Catalogue No.

A7719

Reactivity

Human, Rat

Immunogen

A synthetic peptide of human PSEN2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 50kDa/Observed: Refer to figures

Formulation

PSEN2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PSEN2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

AD4 antibody, PS2 antibody, AD3L antibody, STM2 antibody, CMD1V antibody

Database links

Human UniProt/Swiss-Prot:P49810

Protein names

AD4, PS2, AD3L, STM2, CMD1V

Protein function

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

Protein tissue specificity

Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.

Protein sequence and domain

The PAL motif is required for normal active site conformation.Belongs to the peptidase A22A family.

Protein post-translational modifications

Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments.; Phosphorylated on serine residues.

Protein cellular localization

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .

Background

Alzheimer’s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

Research area

All research areas>Neurobiology>Presenilin
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize PSEN2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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