Rabbit polyclonal PSMA3 antibody (A1245)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PSMA3 antibody (A1245)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

PSMA3 antibody,HC8 antibody,MGC12306 antibody,MGC32631 antibody,PSC3 antibody
HC8 antibody|Macropain subunit C8 antibody|MGC12306 antibody|MGC32631 antibody|Multicatalytic endopeptidase complex subunit C8 antibody|Proteasome (prosome macropain) subunit alpha type 3 antibody|Proteasome alpha 3 subunit antibody|Proteasome component C8 antibody|Proteasome subunit alpha type 3 antibody|Proteasome subunit alpha type-3 antibody|Proteasome subunit C8 antibody|PSA3_HUMAN antibody|PSC8 antibody|psmA3 antibody|Anti-Proteasome 20S alpha 3 antibody [EPR5455] (ab109532)

SCBT cat No: sc-54707|sc-166205|sc-166206|sc-54670|sc-67340|

Name

Rabbit polyclonal PSMA3 antibody

Catalogue No.

A1245

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PSMA3

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 28kDa/Observed: Refer to Figures

Formulation

PSMA3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PSMA3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PSMA3 antibody,HC8 antibody,MGC12306 antibody,MGC32631 antibody,PSC3 antibody

Database links

Human UniProt/Swiss-Prot:P25788

Protein names

PSMA3,HC8,MGC12306,MGC32631,PSC3

Protein function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.

Protein sequence and domain

Belongs to the peptidase T1A family.

Protein cellular localization

Cytoplasm. Nucleus.

Background

The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. It consists of four stacked rings, each with seven distinct subunits. The two outer layers are identical rings composed of alpha subunits (called PSMAs), and the two inner layers are identical rings composed of beta subunits. While the catalytic sites are located on the beta rings (1-3), the alpha subunits are important for assembly and as binding sites for regulatory proteins (4). Seven different alpha and ten different beta proteasome genes have been identified in mammals (5). PA700, PA28, and PA200 are three major protein complexes that function as activators of the 20S proteasome. PA700 binds polyubiquitin with high affinity and associates with the 20S proteasome to form the 26S proteasome, which preferentially degrades poly-ubiquitinated proteins (1-3). The proteasome has a broad substrate spectrum that includes cell cycle regulators, signaling molecules, tumor suppressors, and transcription factors. By controlling the degradation of these intracellular proteins, the proteasome functions in cell cycle regulation, cancer development, immune responses, protein folding, and disease progression (6-9).

Note

AntibodyPlus can customize PSMA3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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