Rabbit polyclonal PSMA6 antibody (A2188)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PSMA6 antibody (A2188)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PSMA6 antibody.

Alternative names:

Check alternative names for the antibody

Expand

IOTA antibody, MGC22756 antibody, MGC2333 antibody, MGC23846 antibody, PROS27 antibody, p27K antibody
27 kDa prosomal protein antibody|IOTA antibody|Macropain iota chain antibody|Macropain subunit iota antibody|MGC22756 antibody|MGC2333 antibody|MGC23846 antibody|Multicatalytic endopeptidase complex iota chain antibody|p27K antibody|PROS 27 antibody|PROS-27 antibody|PROS27 antibody|Prosomal P27K protein antibody|Proteasome (prosome macropain) subunit alpha type 6 antibody|Proteasome iota chain antibody|Proteasome subunit alpha type 6 antibody|Proteasome subunit alpha type-6 antibody|Proteasome subunit iota antibody|PSA6_HUMAN antibody|PSMA 6 antibody|PSMA6 antibody|Anti-Proteasome subunit alpha type 6 antibody [EPR5835] (ab109377)

SCBT cat No: sc-271187|sc-54724|sc-67343|sc-58416|sc-54674|

Name

Rabbit polyclonal PSMA6 antibody

Catalogue No.

A2188

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PSMA6

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 27kDa/Observed: Refer to Figures

Formulation

PSMA6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PSMA6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IOTA antibody, MGC22756 antibody, MGC2333 antibody, MGC23846 antibody, PROS27 antibody, p27K antibody

Database links

Human UniProt/Swiss-Prot:P60900

Protein names

IOTA, MGC22756, MGC2333, MGC23846, PROS27, p27K

Protein function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Protein sequence and domain

Belongs to the peptidase T1A family.

Protein cellular localization

Cytoplasm. Nucleus. Cytoplasm, P-body . Note: Colocalizes with TRIM5 in the cytoplasmic bodies.

Background

The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. It consists of four stacked rings, each with seven distinct subunits. The two outer layers are identical rings composed of alpha subunits (called PSMAs), and the two inner layers are identical rings composed of beta subunits. While the catalytic sites are located on the beta rings (1-3), the alpha subunits are important for assembly and as binding sites for regulatory proteins (4). Seven different alpha and ten different beta proteasome genes have been identified in mammals (5). PA700, PA28, and PA200 are three major protein complexes that function as activators of the 20S proteasome. PA700 binds polyubiquitin with high affinity and associates with the 20S proteasome to form the 26S proteasome, which preferentially degrades poly-ubiquitinated proteins (1-3). The proteasome has a broad substrate spectrum that includes cell cycle regulators, signaling molecules, tumor suppressors, and transcription factors. By controlling the degradation of these intracellular proteins, the proteasome functions in cell cycle regulation, cancer development, immune responses, protein folding, and disease progression (6-9).

Note

AntibodyPlus can customize PSMA6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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