Rabbit polyclonal PSMB8 antibody (A7340)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PSMB8 antibody (A7340)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PSMB8 antibody.

Alternative names:

Check alternative names for the antibody

Expand

JMP antibody, ALDD antibody, LMP7 antibody, NKJO antibody, D6S216 antibody, PSMB5i antibody, RING10 antibody, D6S216E antibody
ALDD antibody|Proteasome subunit beta 5i antibody|Proteasome subunit beta 8 antibody|Proteasome subunit beta type 8 antibody|Proteasome subunit beta type antibody|Proteasome subunit beta type-8 antibody|Proteasome subunit beta-5i antibody|Proteasome subunit Y2 antibody|PSB8_HUMAN antibody|PSMB 8 antibody|PSMB5i antibody|PSMB8 antibody|Really interesting new gene 10 protein antibody|RING 10 antibody|RING10 antibody|Y2 antibody|Anti-Proteasome 20S LMP7 antibody (ab3329)

SCBT cat No: sc-100284|sc-365699|sc-365698|sc-374089|sc-17073|sc-17070|

Name

Rabbit polyclonal PSMB8 antibody

Catalogue No.

A7340

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PSMB8

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 30kDa/Observed: Refer to figures

Formulation

PSMB8 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PSMB8 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

JMP antibody, ALDD antibody, LMP7 antibody, NKJO antibody, D6S216 antibody, PSMB5i antibody, RING10 antibody, D6S216E antibody

Database links

Human UniProt/Swiss-Prot:P28062

Protein names

JMP, ALDD, LMP7, NKJO, D6S216, PSMB5i, RING10, D6S216E

Protein function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.

Protein sequence and domain

Belongs to the peptidase T1B family.

Protein post-translational modifications

Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.

Protein cellular localization

Cytoplasm . Nucleus .

Background

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Note

AntibodyPlus can customize PSMB8 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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