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Rabbit polyclonal PSMC3 antibody (A1986)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal PSMC3 antibody.
Check alternative names for the antibodyExpand
26S protease regulatory subunit 6A antibody|26S proteasome AAA-ATPase subunit RPT5 antibody|Human immunodeficiency virus tat transactivator binding protein 1 antibody|MGC8487 antibody|Proteasome (prosome macropain) 26S subunit ATPase 3 antibody|Proteasome 26S ATPase subunit 3 antibody|Proteasome 26S subunit ATPase 3 antibody|Proteasome subunit P50 antibody|PRS6A_HUMAN antibody|PSMC 3 antibody|PSMC3 antibody|Tat binding protein 1 antibody|TAT-binding protein 1 antibody|TBP-1 antibody|TBP1 antibody|Anti-PSMC3 antibody [EPR12152] – N-terminal (ab171969)
SCBT cat No: sc-100462|
Rabbit polyclonal PSMC3 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human PSMC3
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 49kDa/Observed: Refer to Figures
PSMC3 antibody was tube-contained.
PSMC3 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.
|Protein sequence and domain|| |
Belongs to the AAA ATPase family.
|Protein post-translational modifications|| |
Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
|Protein cellular localization|| |
Cytoplasm . Nucleus . Cytoplasm, P-body . Note: Colocalizes with TRIM5 in the cytoplasmic bodies.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
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|Product type|| |
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