Rabbit polyclonal PSMC3 antibody (A1986)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PSMC3 antibody (A1986)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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TBP1 antibody
26S protease regulatory subunit 6A antibody|26S proteasome AAA-ATPase subunit RPT5 antibody|Human immunodeficiency virus tat transactivator binding protein 1 antibody|MGC8487 antibody|Proteasome (prosome macropain) 26S subunit ATPase 3 antibody|Proteasome 26S ATPase subunit 3 antibody|Proteasome 26S subunit ATPase 3 antibody|Proteasome subunit P50 antibody|PRS6A_HUMAN antibody|PSMC 3 antibody|PSMC3 antibody|Tat binding protein 1 antibody|TAT-binding protein 1 antibody|TBP-1 antibody|TBP1 antibody|Anti-PSMC3 antibody [EPR12152] – N-terminal (ab171969)

SCBT cat No: sc-100462|

Name

Rabbit polyclonal PSMC3 antibody

Catalogue No.

A1986

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PSMC3

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 49kDa/Observed: Refer to Figures

Formulation

PSMC3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PSMC3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

TBP1 antibody

Database links

Human UniProt/Swiss-Prot:P17980

Protein names

TBP1

Protein function

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.

Protein sequence and domain

Belongs to the AAA ATPase family.

Protein post-translational modifications

Sumoylated by UBE2I in response to MEKK1-mediated stimuli.

Protein cellular localization

Cytoplasm . Nucleus . Cytoplasm, P-body . Note: Colocalizes with TRIM5 in the cytoplasmic bodies.

Background

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Research area

All research areas>Synthesis and Degradation>PSMC
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize PSMC3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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