Rabbit polyclonal PSRC1 antibody (A5484)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PSRC1 antibody (A5484)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PSRC1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

DDA3 antibody, FP3214 antibody
DDA3 antibody|DDA3, mouse, homolog of antibody|Differential display and activated by p53 antibody|FP3214 antibody|OTTHUMP00000013785 antibody|OTTHUMP00000013786 antibody|p53-regulated DDA3 antibody|Proline/serine-rich coiled-coil 1 antibody|Proline/serine-rich coiled-coil protein 1 antibody|PSRC1 antibody|PSRC1_HUMAN antibody|Anti-PSRC1 antibody (ab187199)

SCBT cat No: sc-160272|

Name

Rabbit polyclonal PSRC1 antibody

Catalogue No.

A5484

Reactivity

Human

Immunogen

Recombinant protein of human PSRC1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 38kDa/Observed: Refer to Figures

Formulation

PSRC1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PSRC1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DDA3 antibody, FP3214 antibody

Database links

Human UniProt/Swiss-Prot:Q6PGN9

Protein names

DDA3, FP3214

Protein function

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.

Protein tissue specificity

Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.

Protein sequence and domain

Belongs to the PSRC1 family.

Protein post-translational modifications

Phosphorylated during mitosis.

Protein cellular localization

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note: Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.

Background

This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as a microtubule destabilizing protein that controls spindle dynamics and mitotic progression by recruiting and regulating microtubule depolymerases. At least one genetic variation in this gene has been associated with decreased serum levels of low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding different isoforms have been described.

Note

AntibodyPlus can customize PSRC1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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