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Rabbit polyclonal PSRC1 antibody (A5484)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal PSRC1 antibody.
Check alternative names for the antibodyExpand
DDA3 antibody, FP3214 antibody
DDA3 antibody|DDA3, mouse, homolog of antibody|Differential display and activated by p53 antibody|FP3214 antibody|OTTHUMP00000013785 antibody|OTTHUMP00000013786 antibody|p53-regulated DDA3 antibody|Proline/serine-rich coiled-coil 1 antibody|Proline/serine-rich coiled-coil protein 1 antibody|PSRC1 antibody|PSRC1_HUMAN antibody|Anti-PSRC1 antibody (ab187199)
SCBT cat No: sc-160272|
Rabbit polyclonal PSRC1 antibody
|Catalogue No.|| |
Recombinant protein of human PSRC1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 38kDa/Observed: Refer to Figures
PSRC1 antibody was tube-contained.
PSRC1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
DDA3 antibody, FP3214 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
|Protein tissue specificity|| |
Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.
|Protein sequence and domain|| |
Belongs to the PSRC1 family.
|Protein post-translational modifications|| |
Phosphorylated during mitosis.
|Protein cellular localization|| |
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note: Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.
This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as a microtubule destabilizing protein that controls spindle dynamics and mitotic progression by recruiting and regulating microtubule depolymerases. At least one genetic variation in this gene has been associated with decreased serum levels of low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding different isoforms have been described.
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|Product type|| |
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