Rabbit polyclonal PTBP1 antibody (A1831)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PTBP1 antibody (A1831)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PTBP1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

PTB antibody, PTB2 antibody, PTB3 antibody, PTB4 antibody, pPTB antibody, HNRPI antibody, PTB-1 antibody, PTB-T antibody, HNRNPI antibody, HNRNP-I antibody
57 kDa RNA binding protein PPTB 1 antibody|57 kDa RNA-binding protein PPTB-1 antibody|Heterogeneous nuclear ribonucleoprotein I antibody|Heterogeneous Nuclear Ribonucleoprotein Polypeptide I antibody|hnRNP I antibody|HNRNP-I antibody|HNRNPI antibody|HNRPI antibody|MGC10830 antibody|MGC8461 antibody|Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I) antibody|Polypyrimidine Tract Binding Protein 1 antibody|Polypyrimidine tract binding protein antibody|Polypyrimidine tract-binding protein 1 antibody|pPTB antibody|PTB 1 antibody|PTB 2 antibody|PTB 3 antibody|PTB 4 antibody|PTB antibody|PTB T antibody|PTB1 antibody|PTB2 antibody|PTB3 antibody|PTB4 antibody|PTBP 1 antibody|PTBP1 antibody|PTBP1_HUMAN antibody|PTBT antibody|RNA Binding Protein antibody|Anti-PTBP1 antibody (ab5642)

SCBT cat No: sc-73391|sc-515282|sc-16549|sc-16547|sc-56701|

Name

Rabbit polyclonal PTBP1 antibody

Catalogue No.

A1831

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PTBP1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 57kDa/Observed: Refer to Figures

Formulation

PTBP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PTBP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PTB antibody, PTB2 antibody, PTB3 antibody, PTB4 antibody, pPTB antibody, HNRPI antibody, PTB-1 antibody, PTB-T antibody, HNRNPI antibody, HNRNP-I antibody

Database links

Human UniProt/Swiss-Prot:P26599

Protein names

PTB, PTB2, PTB3, PTB4, pPTB, HNRPI, PTB-1, PTB-T, HNRNPI, HNRNP-I

Protein function

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 . In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation .

Protein sequence and domain

Contains 4 RRM (RNA recognition motif) domains.

Protein cellular localization

Nucleus.

Background

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been describ

Research area

All research areas>Transcription Regulators>hnRNP
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize PTBP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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