Rabbit polyclonal PTGDS antibody (A1889)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PTGDS antibody (A1889)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PDS antibody, PGD2 antibody, PGDS antibody, LPGDS antibody, PGDS2 antibody, L-PGDS antibody
Beta trace protein antibody|Beta-trace protein antibody|Cerebrin 28 antibody|Cerebrin-28 antibody|glutathione independent PGD synthase antibody|Glutathione independent PGD synthetase antibody|Glutathione-independent PGD synthase antibody|L PGDS antibody|Lipocalin type prostaglandin D synthase antibody|Lipocalin-type prostaglandin-D synthase antibody|LPGDS antibody|PDS antibody|PGD2 antibody|PGD2 synthase antibody|PGDS antibody|PGDS2 antibody|prostaglandin D synthase antibody|prostaglandin D2 synthase (21 kDa, brain) antibody|prostaglandin D2 synthase (brain) antibody|prostaglandin D2 synthase 21kDa (brain) antibody|Prostaglandin D2 synthase antibody|prostaglandin H2 D isomerase antibody|Prostaglandin-D2 synthase antibody|Prostaglandin-H2 D-isomerase antibody|PTGDS antibody|PTGDS_HUMAN antibody|RP23-47P18.11-006 antibody|Anti-Prostaglandin D Synthase (Lipocalin) antibody [EP12357] (ab182141)

SCBT cat No: sc-14826|

Name

Rabbit polyclonal PTGDS antibody

Catalogue No.

A1889

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PTGDS

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 21kDa/Observed: Refer to figures

Formulation

PTGDS antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PTGDS antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PDS antibody, PGD2 antibody, PGDS antibody, LPGDS antibody, PGDS2 antibody, L-PGDS antibody

Database links

Human UniProt/Swiss-Prot:P41222

Protein names

PDS, PGD2, PGDS, LPGDS, PGDS2, L-PGDS

Protein function

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.

Protein tissue specificity

Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes.

Protein sequence and domain

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.Belongs to the calycin superfamily. Lipocalin family.

Protein post-translational modifications

N- and O-glycosylated. Both N-glycosylation recognition sites are almost quantitatively occupied by N-glycans of the biantennary complex type, with a considerable proportion of structures bearing a bisecting GlcNAc. N-glycan at Asn-78: dHex1Hex5HexNAc4. Agalacto structure as well as sialylated and nonsialylated oligosaccharides bearing alpha2-3- and/or alpha2-6-linked NeuNAc are present.

Protein cellular localization

Rough endoplasmic reticulum . Nucleus membrane . Golgi apparatus . Cytoplasm, perinuclear region . Secreted . Note: Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.

Background

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.

Note

AntibodyPlus can customize PTGDS antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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