Rabbit polyclonal PTGS2 antibody (A1253)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PTGS2 antibody (A1253)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:4000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PTGS2 antibody,COX-2 antibody,COX2 antibody,GRIPGHS antibody,PGG/HS antibody,PGHS-2 antibody,PHS-2 antibody,hCox-2 antibody, cox2 antibody
COX 2 antibody|COX-2 antibody|COX2 antibody|Cyclooxygenase 2 antibody|Cyclooxygenase 2b antibody|Cyclooxygenase antibody|Cyclooxygenase-2 antibody|Cyclooxygenase2 antibody|EC 1.14.99.1 antibody|fj02a10 antibody|Glucocorticoid-regulated inflammatory cyclooxygenase antibody|Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase antibody|GRIPGHS antibody|hCox 2 antibody|Macrophage activation-associated marker protein P71/73 antibody|OTTHUMP00000033524 antibody|PES-2 antibody|PGG/HS antibody|PGH synthase 2 antibody|PGH2_HUMAN antibody|PGHS 2 antibody|PGHS-2 antibody|PGHS2 antibody|PHS 2 antibody|PHS II antibody|PHS2 antibody|Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody|Prostaglandin endoperoxide synthase 2 antibody|Prostaglandin G/H synthase 2 antibody|Prostaglandin G/H synthase 2 precursor antibody|Prostaglandin G/H synthase and cyclooxygenase antibody|Prostaglandin G/H synthase antibody|Prostaglandin H2 synthase 2 antibody|prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody|Prostaglandin-endoperoxide synthase 2 antibody|PTGS2 antibody|ptgs2a antibody|TIS10 antibody|TIS10 protein antibody|unp1239 antibody|wu:fj02a10 antibody|Anti-COX2 / Cyclooxygenase 2 antibody (ab15191)

SCBT cat No: sc-19999|sc-1745|sc-166475|sc-514489|sc-376861|sc-7951|sc-23984|

Name

Rabbit polyclonal PTGS2 antibody

Catalogue No.

A1253

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PTGS2

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:1000 – 1:4000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 68kDa/Observed: Refer to Figures

Formulation

PTGS2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PTGS2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PTGS2 antibody,COX-2 antibody,COX2 antibody,GRIPGHS antibody,PGG/HS antibody,PGHS-2 antibody,PHS-2 antibody,hCox-2 antibody, cox2 antibody

Database links

Human UniProt/Swiss-Prot:P35354

Protein names

PTGS2,COX-2,COX2,GRIPGHS,PGG/HS,PGHS-2,PHS-2,hCox-2, cox2

Protein function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Protein sequence and domain

Belongs to the prostaglandin G/H synthase family.; Contains 1 EGF-like domain.

Protein post-translational modifications

S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526.

Protein cellular localization

Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.

Background

Cyclooxygenase1 (Cox1) and cyclooxygenase2 (Cox2), family members with 60% homology in humans, catalyze prostaglandin production from arachidonic acid (1,2). While Cox1 expression is constitutive in most tissues, Cox2 expression is induced by lipopolysaccharide (LPS) and peptidoglycan (PGN) (3). PGN activates Ras, leading to phosphorylation of Raf at Ser338 and Erk1/2 at Tyr204. The activation of MAP kinase signaling results in subsequent activation of IKKalpha/beta, phosphorylation of IkappaBalpha at Ser32/36, and NF-kappaB activation. Finally, activation of the transcription factor NF-kappaB is responsible for the induction of Cox2 expression (4). LPS and PGN induce the clinical manifestations of arthritis and bacterial infections, such as inflammation, fever, and septic shock (5), making Cox2 a useful target for therapeutic anti-inflammatory drugs (3). Cox1 and Cox2 also play a role in the neuropathology of Alzheimer’s disease by potentiating gamma-secretase activity and beta-amyloid generation (6).

Note

AntibodyPlus can customize PTGS2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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