Rabbit polyclonal PTK7 antibody (A9839)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PTK7 antibody (A9839)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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SCBT cat No: sc-100304|

Name

Rabbit polyclonal PTK7 antibody

Catalogue No.

A9839

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PTK7

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 118kDa/Observed: Refer to figures

Formulation

PTK7 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PTK7 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:Q13308

Protein function

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Protein tissue specificity

Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.

Protein sequence and domain

The protein kinase domain is predicted to be catalytically inactive.Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.; Contains 7 Ig-like C2-type (immunoglobulin-like) domains.; Contains 1 protein kinase domain.

Protein post-translational modifications

MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.

Protein cellular localization

Membrane ; Single-pass type I membrane protein . Cell junction . Note: Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.

Research area

All research areas>Membrane Receptors>Cholecystokinin Receptor
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize PTK7 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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