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Rabbit polyclonal PTPN1 antibody (A1590)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal PTPN1 antibody.
Check alternative names for the antibodyExpand
PTP1B antibody|Non receptor tyrosine phosphatase 1 antibody|Protein phosphotyrosylphosphatase 1B antibody|Protein tyrosine phosphatase 1B antibody|Protein tyrosine phosphatase non receptor type 1 antibody|Protein tyrosine phosphatase placental antibody|Protein-tyrosine phosphatase 1B antibody|PTN1_HUMAN antibody|PTP 1B antibody|PTP-1B antibody|PTPN 1 antibody|PTPN1 antibody|Tyrosine protein phosphatase non receptor type 1 antibody|Tyrosine-protein phosphatase non-receptor type 1 antibody|Anti-PTP1B antibody [4F8F11] (ab201974)
SCBT cat No: sc-56960|sc-133115|sc-1719|sc-133259|sc-14021|sc-133258|sc-1718|
Rabbit polyclonal PTPN1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human PTPN1
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 50kDa/Observed: Refer to Figures
PTPN1 antibody was tube-contained.
PTPN1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
|Protein sequence and domain|| |
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.; Contains 1 tyrosine-protein phosphatase domain.
|Protein post-translational modifications|| |
Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.; Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50.; S-nitrosylation of Cys-215 inactivates the enzyme activity.; Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.
|Protein cellular localization|| |
Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Note: Interacts with EPHA3 at the cell membrane.
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
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|Product type|| |
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