Rabbit polyclonal PTPN6 antibody (A1446)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PTPN6 antibody (A1446)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PTPN6 antibody.

Alternative names:

Check alternative names for the antibody

Expand

PTPN6 antibody,HCP antibody,HCPH antibody,HPTP1C antibody,PTP-1C antibody,SH-PTP1 antibody,SHP-1 antibody,SHP-1L antibody,SHP1 antibody, SH-PTP1 antibody
70Z-SHP antibody|EC 3.1.3.48 antibody|HCP antibody|HCPH antibody|Hematopoietic cell phosphatase antibody|Hematopoietic cell protein tyrosine phosphatase antibody|Hematopoietic cell protein-tyrosine phosphatase antibody|HPTP1C antibody|Protein tyrosine phosphatase 1C antibody|Protein tyrosine phosphatase non receptor type 6 antibody|Protein tyrosine phosphatase SHP1 antibody|Protein-tyrosine phosphatase 1C antibody|protein-tyrosine phosphatase SHP 1 antibody|Protein-tyrosine phosphatase SHP-1 antibody|PTN6_HUMAN antibody|PTP 1C antibody|PTP-1C antibody|PTP1C antibody|Ptpn6 antibody|SH PTP 1 antibody|SH PTP1 antibody|SH-PTP1 antibody|SHP 1 antibody|SHP 1L antibody|SHP1 antibody|SHP1L antibody|tyrosine protein phosphatase non receptor type 6 antibody|Tyrosine-protein phosphatase non-receptor type 6 antibody|Anti-SHP1 antibody [Y476] (ab32559)

SCBT cat No: sc-135780|sc-135781|sc-135782|sc-293147|sc-101798|sc-101799|sc-136227|sc-101087|sc-33371|sc-136094|sc-130857|

Name

Rabbit polyclonal PTPN6 antibody

Catalogue No.

A1446

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PTPN6

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 65kDa/Observed: Refer to Figures

Formulation

PTPN6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PTPN6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PTPN6 antibody,HCP antibody,HCPH antibody,HPTP1C antibody,PTP-1C antibody,SH-PTP1 antibody,SHP-1 antibody,SHP-1L antibody,SHP1 antibody, SH-PTP1 antibody

Database links

Human UniProt/Swiss-Prot:P29350

Protein names

PTPN6,HCP,HCPH,HPTP1C,PTP-1C,SH-PTP1,SHP-1,SHP-1L,SHP1, SH-PTP1

Protein function

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

Protein tissue specificity

Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

Protein sequence and domain

The N-terminal SH2 domain functions as an auto-inhibitory domain, blocking the catalytic domain in the ligand-free close conformation.Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.; Contains 2 SH2 domains.; Contains 1 tyrosine-protein phosphatase domain.

Protein post-translational modifications

Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity.

Protein cellular localization

Cytoplasm. Nucleus. Note: In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1.

Background

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain (1). SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth (2). Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation (3). Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation (4). Because SHP-1 downregulates various proliferation pathways, SHP-1 is considered a potential tumor suppressor and angiogenesis regulator (5,6).

Research area

All research areas>Kinases and Phosphatases>SH-PTP
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize PTPN6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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