Rabbit polyclonal PTPRE antibody (A7209)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PTPRE antibody (A7209)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PTPE antibody, HPTPE antibody, R-PTP-EPSILON antibody
DKFZp313F1310 antibody|FLJ57799 antibody|FLJ58245 antibody|HPTPE antibody|Protein tyrosine phosphatase epsilon antibody|Protein tyrosine phosphatase receptor type E antibody|Protein tyrosine phosphatase receptor type epsilon antibody|Protein tyrosine phosphatase receptor type epsilon polypeptide antibody|Protein-tyrosine phosphatase epsilon antibody|PTPE antibody|Ptpre antibody|PTPRE_HUMAN antibody|R PTP Epsilon antibody|R-PTP-epsilon antibody|Receptor-type tyrosine-protein phosphatase epsilon antibody|Anti-PTP epsilon antibody [EPR6715] (ab126788)

SCBT cat No: sc-1117|sc-367762|

Name

Rabbit polyclonal PTPRE antibody

Catalogue No.

A7209

Reactivity

Human

Immunogen

Recombinant protein of human PTPRE

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 81kDa/Observed: Refer to figures

Formulation

PTPRE antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PTPRE antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PTPE antibody, HPTPE antibody, R-PTP-EPSILON antibody

Database links

Human UniProt/Swiss-Prot:P23469

Protein names

PTPE, HPTPE, R-PTP-EPSILON

Protein function

Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).; Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity).; Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).

Protein tissue specificity

Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells).

Protein sequence and domain

The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity (By similarity).Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.; Contains 2 tyrosine-protein phosphatase domains.

Protein post-translational modifications

A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3.; Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu.; Isoform 1 is glycosylated.

Protein cellular localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cytoplasm. Note: Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity).; Isoform 3: Cytoplasm.

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels.

Research area

All research areas>Kinases and Phosphatases>PTP
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize PTPRE antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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