Rabbit polyclonal PTRH2 antibody (A6466)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal PTRH2 antibody (A6466)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal PTRH2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

BIT1 antibody, PTH2 antibody, CFAP37 antibody, CGI-147 antibody
Bcl 2 inhibitor of transcription 1 antibody|Bcl-2 inhibitor of transcription 1 antibody|BIT 1 antibody|BIT1 antibody|CGI 147 antibody|CGI147 antibody|mitochondrial antibody|Peptidyl tRNA hydrolase 2 mitochondrial antibody|Peptidyl-tRNA hydrolase 2 antibody|PTH 2 antibody|PTH2 antibody|PTH2_HUMAN antibody|PTRH 2 antibody|PTRH2 antibody|Anti-PTRH2 antibody (ab36990)

SCBT cat No:

Name

Rabbit polyclonal PTRH2 antibody

Catalogue No.

A6466

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human PTRH2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 19kDa/Observed: Refer to Figures

Formulation

PTRH2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

PTRH2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BIT1 antibody, PTH2 antibody, CFAP37 antibody, CGI-147 antibody

Database links

Human UniProt/Swiss-Prot:Q9Y3E5

Protein names

BIT1, PTH2, CFAP37, CGI-147

Protein function

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.; Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.

Protein sequence and domain

Belongs to the PTH2 family.

Protein post-translational modifications

Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

Protein cellular localization

Mitochondrion.

Background

The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms.

Note

AntibodyPlus can customize PTRH2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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