Rabbit polyclonal QKI antibody (A7043)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal QKI antibody (A7043)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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QK antibody, Hqk antibody, QK1 antibody, QK3 antibody, hqkI antibody
DKFZp586I0923 antibody|HKQ antibody|Homolog of mouse quaking QKI KH domain RNA binding protein antibody|Hqk antibody|HQK1 antibody|HqkI antibody|OTTHUMP00000017581 antibody|OTTHUMP00000017582 antibody|OTTHUMP00000017583 antibody|Protein quaking antibody|QK antibody|QK1 antibody|QK3 antibody|QKI antibody|QKI_HUMAN antibody|QKI1 antibody|Quaking homolog antibody|Quaking homolog KH domain RNA binding antibody|Quaking homolog KH domain RNA binding mouse antibody|Quaking isoform 1 antibody|Quaking protein antibody|RNA binding protein HQK antibody|Anti-QK1 antibody – C-terminal (ab195960)

SCBT cat No: sc-103851|

Name

Rabbit polyclonal QKI antibody

Catalogue No.

A7043

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human QKI

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 38kDa/Observed: Refer to figures

Formulation

QKI antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

QKI antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

QK antibody, Hqk antibody, QK1 antibody, QK3 antibody, hqkI antibody

Database links

Human UniProt/Swiss-Prot:Q96PU8

Protein names

QK, Hqk, QK1, QK3, hqkI

Protein function

RNA-binding protein that plays a central role in myelinization . Binds to the 5′-NACUAAY-N(1,20)-UAAY-3′ RNA core sequence. Regulates target mRNA stability . In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia . Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).

Protein tissue specificity

Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients.

Protein sequence and domain

The KH domain and the Qua2 region are involved in RNA binding.Contains 1 KH domain.

Protein post-translational modifications

Methylated by PRMT1.; Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).

Protein cellular localization

Nucleus . Cytoplasm .

Background

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize QKI antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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