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Rabbit polyclonal RAB17 antibody (A7831)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal RAB17 antibody.
Check alternative names for the antibodyExpand
AW413472 antibody||Anti-Rab17 antibody (ab155135)
SCBT cat No:
Rabbit polyclonal RAB17 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human RAB17
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 23kDa/Observed: Refer to figures
RAB17 antibody was tube-contained.
RAB17 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.
|Protein tissue specificity|| |
Expressed in melanocytes (at protein level).
|Protein sequence and domain|| |
Belongs to the small GTPase superfamily. Rab family.
|Protein cellular localization|| |
Recycling endosome membrane ; Lipid-anchor ; Cytoplasmic side . Melanosome . Cell projection, dendrite . Note: May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine.
The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993
AntibodyPlus can customize RAB17 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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