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Rabbit polyclonal RAB23 antibody (A7979)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal RAB23 antibody.
Check alternative names for the antibodyExpand
DKFZp781H0695 antibody||Anti-RAB23 antibody (ab169491)
SCBT cat No: sc-130248|sc-292960|sc-169083|
Rabbit polyclonal RAB23 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human RAB23
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 27kDa/Observed: Refer to figures
RAB23 antibody was tube-contained.
RAB23 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.
|Protein sequence and domain|| |
Belongs to the small GTPase superfamily. Rab family.
|Protein cellular localization|| |
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm . Cytoplasmic vesicle, autophagosome . Endosome membrane . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side . Note: Recruited to phagosomes containing S.aureus or M.tuberculosis.
This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants.
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|Product type|| |
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