Rabbit polyclonal RAD23A antibody (A3188)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RAD23A antibody (A3188)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RAD23A antibody.

Alternative names:

Check alternative names for the antibody

Expand

HR23A antibody, HHR23A antibody
hHR 23A antibody|hHR23A antibody|HR23A antibody|MGC111083 antibody|RAD 23a antibody|RAD23 homolog A (S. cerevisiae) antibody|RAD23 homolog A antibody|RAD23 yeast homolog A antibody|RAD23A antibody|RD23A_HUMAN antibody|UV excision repair protein RAD23 antibody|UV excision repair protein RAD23 homolog A antibody|Anti-hHR23A antibody (ab55725)

SCBT cat No: sc-365669|sc-67162|

Name

Rabbit polyclonal RAD23A antibody

Catalogue No.

A3188

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RAD23A

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 39kDa/Observed: Refer to Figures

Formulation

RAD23A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RAD23A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HR23A antibody, HHR23A antibody

Database links

Human UniProt/Swiss-Prot:P54725

Protein names

HR23A, HHR23A

Protein function

Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ‘Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ‘Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.

Protein sequence and domain

The ubiquitin-like domain mediates interaction with ATXN3.; The ubiquitin-like (UBL) and the UBA (ubiquitin-associated) domains interact intramolecularly in a highly dynamic manner, as each UBA domain competes for an overlapping UBL domain surface. Binding of ubiquitin or proteasome subunit PSMD4 disrupt the UBL-UBA domain interactions and drive RAD23A in to an open conformation.Belongs to the RAD23 family.; Contains 2 UBA domains.; Contains 1 ubiquitin-like domain.

Protein cellular localization

Nucleus.

Background

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms.

Research area

All research areas>Tumor Suppressor/Apoptosis>Rad
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize RAD23A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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