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Rabbit polyclonal RAD23A antibody (A3188)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal RAD23A antibody.
Check alternative names for the antibodyExpand
HR23A antibody, HHR23A antibody
hHR 23A antibody|hHR23A antibody|HR23A antibody|MGC111083 antibody|RAD 23a antibody|RAD23 homolog A (S. cerevisiae) antibody|RAD23 homolog A antibody|RAD23 yeast homolog A antibody|RAD23A antibody|RD23A_HUMAN antibody|UV excision repair protein RAD23 antibody|UV excision repair protein RAD23 homolog A antibody|Anti-hHR23A antibody (ab55725)
SCBT cat No: sc-365669|sc-67162|
Rabbit polyclonal RAD23A antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human RAD23A
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 39kDa/Observed: Refer to Figures
RAD23A antibody was tube-contained.
RAD23A antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
HR23A antibody, HHR23A antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ‘Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ‘Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.
|Protein sequence and domain|| |
The ubiquitin-like domain mediates interaction with ATXN3.; The ubiquitin-like (UBL) and the UBA (ubiquitin-associated) domains interact intramolecularly in a highly dynamic manner, as each UBA domain competes for an overlapping UBL domain surface. Binding of ubiquitin or proteasome subunit PSMD4 disrupt the UBL-UBA domain interactions and drive RAD23A in to an open conformation.Belongs to the RAD23 family.; Contains 2 UBA domains.; Contains 1 ubiquitin-like domain.
|Protein cellular localization|| |
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms.
AntibodyPlus can customize RAD23A antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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