Rabbit polyclonal RAD23B antibody (A1034)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RAD23B antibody (A1034)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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RAD23B antibody,HHR23B antibody,HR23B antibody,P58 antibody
hHR 23b antibody|hHR23B antibody|HR 23B antibody|HR23B antibody|mHR 23B antibody|mHR23B antibody|p58 antibody|RAD 23B antibody|RAD23 (S. cerevisiae) homolog B antibody|RAD23 homolog B (S. cerevisiae) antibody|RAD23 homolog B antibody|RAD23 yeast homolog of B antibody|Rad23b antibody|RD23B_HUMAN antibody|UV excision repair protein RAD23 homolog B antibody|XP C repair complementing complex 58 kDa antibody|XP C repair complementing complex 58 kDa protein antibody|XP C repair complementing protein antibody|XP-C repair-complementing complex 58 kDa protein antibody|XPC repair complementing complex 58 kDa antibody|XPC repair complementing complex 58 kDa protein antibody|XPC repair complementing protein antibody|Anti-hHR23b antibody (ab86781)

SCBT cat No: sc-136052|sc-166507|sc-377409|sc-390019|sc-67225|sc-137088|sc-49042|

Name

Rabbit polyclonal RAD23B antibody

Catalogue No.

A1034

Reactivity

Human, Mouse

Immunogen

A synthetic peptide of human RAD23B

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:100 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 43kDa/Observed: Refer to Figures

Formulation

RAD23B antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RAD23B antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RAD23B antibody,HHR23B antibody,HR23B antibody,P58 antibody

Database links

Human UniProt/Swiss-Prot:P54727

Protein names

RAD23B,HHR23B,HR23B,P58

Protein function

Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.; Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.; The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5′-to-3′ direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5′ and 3′ of a cisplatin lesion with a preference for the 5′ side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.

Protein sequence and domain

The ubiquitin-like domain mediates interaction with ATXN3.Belongs to the RAD23 family.; Contains 1 STI1 domain.; Contains 2 UBA domains.; Contains 1 ubiquitin-like domain.

Protein cellular localization

Nucleus. Cytoplasm. Note: The intracellular distribution is cell cycle dependent. Localized to the nucleus and the cytoplasm during G1 phase. Nuclear levels decrease during S-phase; upon entering mitosis, relocalizes in the cytoplasm without association with chromatin.

Background

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]

Research area

All research areas>Tumor Suppressor/Apoptosis>Rad
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize RAD23B antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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