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Rabbit polyclonal RAD9A antibody (A1890)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal RAD9A antibody.
Check alternative names for the antibodyExpand
Cell cycle checkpoint control protein antibody|Cell cycle checkpoint control protein RAD9A antibody|DNA repair exonuclease rad9 homolog A antibody|hRAD 9 antibody|hRAD9 antibody|Rad 9 antibody|RAD 9A antibody|RAD9 (S pombe) homolog antibody|RAD9 homolog A antibody|RAD9 homolog antibody|Rad9a antibody|RAD9A_HUMAN antibody|Anti-Rad9 antibody [93A535] (ab13600)
SCBT cat No: sc-136053|sc-74463|sc-166457|sc-74464|sc-10465|sc-8324|sc-32489|
Rabbit polyclonal RAD9A antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human RAD9A
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 42kDa/Observed: Refer to Figures
RAD9A antibody was tube-contained.
RAD9A antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3′-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3′->5′ double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
|Protein sequence and domain|| |
Belongs to the rad9 family.
|Protein post-translational modifications|| |
Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
|Protein cellular localization|| |
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3′ to 5′ exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
AntibodyPlus can customize RAD9A antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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