Rabbit polyclonal RALBP1 antibody (A1140)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal RALBP1 antibody (A1140)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal RALBP1 antibody.

Alternative names:

Check alternative names for the antibody

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RALBP1 antibody,RIP1 antibody,RLIP1 antibody,RLIP76 antibody
RLIP1 antibody|76 kDa Ral-interacting protein antibody|76-kDa Ral-interacting protein antibody|Dinitrophenyl S-glutathione ATPase antibody|DNP-SG ATPase antibody|Ral-interacting protein 1 antibody|Ral-interacting protein 1, 76-KD antibody|RalA-binding protein 1 antibody|RalBP1 antibody|RBP1_HUMAN antibody|RIP1 antibody|RLIP1 antibody|RLIP76 antibody|Anti-RALBP1 antibody (ab56815)

SCBT cat No: sc-1527|sc-48337|sc-28575|

Name

Rabbit polyclonal RALBP1 antibody

Catalogue No.

A1140

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human RALBP1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 76kDa/Observed: Refer to Figures

Formulation

RALBP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

RALBP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RALBP1 antibody,RIP1 antibody,RLIP1 antibody,RLIP76 antibody

Database links

Human UniProt/Swiss-Prot:Q15311

Protein names

RALBP1,RIP1,RLIP1,RLIP76

Protein function

Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.

Protein tissue specificity

Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.

Protein sequence and domain

Contains 1 Rho-GAP domain.

Protein cellular localization

Membrane ; Peripheral membrane protein .

Background

The RalA binding protein 1 (RalBP1 or RLIP76) was originally identified as a GTP-RalA associated protein that acted as a downstream RalA effector in regulating Ral-Ras signaling (1). RalBP1 interacts with RalA and the endocytosis protein REPS2 (POB1) through its carboxy-terminal Ral binding domain. RalBP1 has an intrinsic GTPase activating function and interacts with Cdc42 through its centrally located Rho-GAP domain (1-3). A protein complex containing RalBP1/POB1/RalA regulates endocytosis of membrane receptors (4). RalBP1 also functions as a non-ABC transporter that catalyzes the ATP-dependent transport of numerous xenobiotics, including glutathione conjugates and some chemotherapeutic agents. RalBP1 transporter activity may play an important role in detoxification, drug resistance and the stress response (5-7). Increased expression of RalBP1 protein is associated with some forms of cancer and regression of cancer xenografts results from RalBP1 inhibition (8,9). Evidence to date suggests that RalBP1 may be a promising therapeutic target for cancer therapy.

Note

AntibodyPlus can customize RALBP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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